Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7467866 | 0.83 | IDE (0.40) | ALOX15POLBLMNAKMT2AMEN1 | |
| SCHEMBL4621983 | 0.82 | KCNE1 (0.45) | POLB | |
| SCHEMBL7461292 | 0.81 | KMT2A (0.45) | POLBLMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL7474303 | 0.81 | TRPV1 (0.46) | LMNAKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7472708 | 0.80 | MAPT (0.48) | LMNAKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8477642 | 0.78 | TRPV1 (0.42) | L3MBTL1ALOX15POLBLMNAKCNH2 | |
| SCHEMBL7469462 | 0.77 | TRPV1 (0.38) | LMNAKCNH2KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL7478341 | 0.77 | ALDH1A1 (0.48) | POLBLMNAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL7468807 | 0.77 | KCNE1 (0.40) | KMT2AMEN1 | |
| SCHEMBL4621868 | 0.76 | KMT2A (0.42) | KMT2AMEN1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0905131-B1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | AVENTIS PHARMA GMBH (DE) | 2002-04-10 | — | — | EP | disclosed |
| EP-0905131-A1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-03-31 | — | — | EP | disclosed |