Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KCNE1 | P15382 | 3/20 | 0.40 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7470001 | 0.91 | KCNE1 (0.42) | KCNE1KCNQ1TRPV1CYP3A4 | |
| SCHEMBL7468844 | 0.89 | TRPV1 (0.42) | SMN1; SMN2KCNE1KCNQ1TRPV1CYP3A4 | |
| SCHEMBL7477267 | 0.86 | ALDH1A1 (0.43) | KCNE1KCNQ1TRPV1MEN1KMT2A | |
| SCHEMBL7477208 | 0.85 | HSD17B10 (0.41) | KCNE1KCNQ1TRPV1CYP3A4MEN1 | |
| SCHEMBL4623467 | 0.85 | TRPV1 (0.42) | SMN1; SMN2KCNE1KCNQ1TRPV1CYP3A4 | |
| SCHEMBL7476073 | 0.85 | KCNE1 (0.40) | KCNE1KCNQ1TRPV1CYP3A4MEN1 | |
| SCHEMBL7476659 | 0.83 | KCNE1 (0.40) | KCNE1KCNQ1TRPV1CYP3A4 | |
| SCHEMBL7468807 | 0.83 | KCNE1 (0.40) | KCNE1KCNQ1TRPV1CYP3A4MEN1 | |
| SCHEMBL7477380 | 0.82 | TRPV1 (0.42) | KCNE1KCNQ1TRPV1CYP3A4 | |
| SCHEMBL7471017 | 0.82 | MAPK1 (0.44) | SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0905131-B1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | AVENTIS PHARMA GMBH (DE) | 2002-04-10 | — | — | EP | disclosed |
| EP-0905131-A1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-03-31 | — | — | EP | disclosed |