Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | EP300 | Q09472 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7473247 | 0.90 | NR1H2 (0.47) | NR1H2ESR2NPC1RAB9AUSP30 | |
| SCHEMBL7468971 | 0.84 | ITGB3 (0.42) | NR1H2ESR2NPC1RAB9AUSP30 | |
| SCHEMBL7481405 | 0.83 | NR1H2 (0.42) | NR1H2ESR2NPC1RAB9AGPR119 | |
| Hydrochloric Acid SCHEMBL7472463 | 0.82 | DRD3 (0.42) | MAPTALDH1A1KDM4ELMNAEP300 | |
| SCHEMBL7465981 | 0.81 | NR1H2 (0.40) | NR1H2ESR2NPC1RAB9AGPR119 | |
| SCHEMBL20929267 | 0.78 | NR1H2 (0.64) | NR1H2ESR2NPC1RAB9AUSP30 | |
| SCHEMBL8565729 | 0.77 | NR1H2 (0.45) | NR1H2ESR2NPC1RAB9AUSP30 | |
| SCHEMBL7478863 | 0.77 | NR1H2 (0.54) | NR1H2ESR2NPC1RAB9AUSP30 | |
| SCHEMBL7477263 | 0.77 | USP30 (0.51) | NR1H2ESR2NPC1RAB9AUSP30 | |
| SCHEMBL7468291 | 0.76 | NR1H2 (0.38) | NR1H2ESR2NPC1RAB9AGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0777667-A1 | CYCLIC BENZAZEPINE UREA DERIVATIVES WITH AGGREGATION-INHIBITING EFFECT | Dr. Karl Thomae GmbH (DE) | 1997-06-11 | — | — | EP | disclosed |
| WO-1996005194-A1 | CYCLIC BENZAZEPINE UREA DERIVATIVES WITH AGGREGATION-INHIBITING EFFECT | DR. KARL THOMAE GMBH (DE) | 1996-02-22 | — | — | WO | disclosed |