Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 1/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.41 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.34 |
| ▸ | CCR2 | P41597 | 3/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CCRL2 | O00421 | 4/20 | 0.32 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.30 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21657083 | 0.80 | OPRL1 (0.43) | OPRL1IRAK4CCR2KCNH2CCRL2 | |
| SCHEMBL7478542 | 0.79 | GRIA2 (0.44) | GRIA1GRIA2GRIA3OPRL1CCR2 | |
| SCHEMBL7468190 | 0.77 | GRIA2 (0.45) | GRIA1GRIA2GRIA3OPRL1KCNH2 | |
| SCHEMBL17148512 | 0.76 | OPRL1 (0.47) | OPRL1IRAK4CCR2KCNH2CCRL2 | |
| SCHEMBL7469275 | 0.75 | GRIA2 (0.47) | GRIA1GRIA2GRIA3OPRL1GRIA4 | |
| SCHEMBL7473870 | 0.74 | NPY5R (0.38) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL7471124 | 0.72 | GRIA2 (0.44) | GRIA1GRIA2GRIA3OPRL1GRIA4 | |
| SCHEMBL7475999 | 0.70 | GRIA1 (0.38) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL7467188 | 0.70 | GRIA2 (0.42) | GRIA1GRIA2GRIA3OPRL1GRIA4 | |
| SCHEMBL12844429 | 0.69 | OPRL1 (0.44) | OPRL1IRAK4CCR2KCNH2CCRL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0937708-B1 | Sulphonamide derivatives | LILLY CO ELI (US) | 2002-12-18 | — | — | EP | disclosed |
| US-6362230-B1 | ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY | 2002-03-26 | — | — | US | disclosed |
| EP-0937708-A2 | sulphonamide derivatives | ELI LILLY AND COMPANY (US) | 1999-08-25 | — | — | EP | disclosed |