Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 2/20 | 0.42 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.42 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | CCR1 | P32246 | 2/20 | 0.32 |
| ▸ | GRIA4 | P48058 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7469275 | 0.83 | GRIA2 (0.47) | GRIA2GRIA1GRIA3GRIA4POLB | |
| SCHEMBL7468190 | 0.78 | GRIA2 (0.45) | GRIA2GRIA1GRIA3CCR1GRIA4 | |
| SCHEMBL7471124 | 0.77 | GRIA2 (0.44) | GRIA2GRIA1GRIA3GRIA4OPRM1 | |
| SCHEMBL7478542 | 0.73 | GRIA2 (0.44) | GRIA2GRIA1GRIA3HTTGRIA4 | |
| SCHEMBL7474379 | 0.72 | GRIA2 (0.43) | GRIA2GRIA1GRIA3CCR1GRIA4 | |
| SCHEMBL7477288 | 0.70 | GRIA1 (0.41) | GRIA2GRIA1GRIA3GRIA4OPRL1 | |
| SCHEMBL7894069 | 0.67 | GRIA2 (0.39) | GRIA2GRIA1GRIA3GRIA4SMN1; SMN2 | |
| SCHEMBL7473870 | 0.66 | NPY5R (0.38) | GRIA2GRIA1GRIA3GRIA4KDM4E | |
| SCHEMBL7474858 | 0.65 | GRIA1 (0.44) | GRIA2GRIA1GRIA3GRIA4SMN1; SMN2 | |
| SCHEMBL7469005 | 0.65 | GRIA1 (0.52) | GRIA2GRIA1GRIA3GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0937708-B1 | Sulphonamide derivatives | LILLY CO ELI (US) | 2002-12-18 | — | — | EP | disclosed |
| US-6362230-B1 | ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY | 2002-03-26 | — | — | US | disclosed |
| EP-0937708-A2 | sulphonamide derivatives | ELI LILLY AND COMPANY (US) | 1999-08-25 | — | — | EP | disclosed |