Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 2/20 | 0.38 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.38 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.38 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.34 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7474379 | 0.82 | GRIA2 (0.43) | NPY5RGRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL7478542 | 0.77 | GRIA2 (0.44) | NPY5RGRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL7470281 | 0.76 | NPY5R (0.38) | NPY5RGRIA2GRIA1GRIA3PKM | |
| SCHEMBL7469275 | 0.76 | GRIA2 (0.47) | NPY5RGRIA2GRIA1GRIA3ALDH1A1 | |
| SCHEMBL7477288 | 0.74 | GRIA1 (0.41) | GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL7468190 | 0.71 | GRIA2 (0.45) | NPY5RGRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL7477103 | 0.71 | GRIA2 (0.40) | NPY5RGRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL7471124 | 0.68 | GRIA2 (0.44) | NPY5RGRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL7894069 | 0.67 | GRIA2 (0.39) | NPY5RGRIA2GRIA1GRIA3ALDH1A1 | |
| SCHEMBL7467188 | 0.66 | GRIA2 (0.42) | NPY5RGRIA2GRIA1GRIA3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0937708-B1 | Sulphonamide derivatives | LILLY CO ELI (US) | 2002-12-18 | — | — | EP | disclosed |
| US-6362230-B1 | ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY | 2002-03-26 | — | — | US | disclosed |
| EP-0937708-A2 | sulphonamide derivatives | ELI LILLY AND COMPANY (US) | 1999-08-25 | — | — | EP | disclosed |