Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 3/20 | 0.44 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.44 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.32 |
| ▸ | GRIA4 | P48058 | 9/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7469275 | 0.83 | GRIA2 (0.47) | GRIA2GRIA1GRIA3NPY5RGRIA4 | |
| SCHEMBL7468190 | 0.81 | GRIA2 (0.45) | GRIA2GRIA1GRIA3NPY5RGRIA4 | |
| SCHEMBL7467188 | 0.77 | GRIA2 (0.42) | GRIA2GRIA1GRIA3NPY5RGRIA4 | |
| SCHEMBL7478542 | 0.75 | GRIA2 (0.44) | GRIA2GRIA1GRIA3NPY5RGRIA4 | |
| SCHEMBL7474379 | 0.74 | GRIA2 (0.43) | GRIA2GRIA1GRIA3NPY5RGRIA4 | |
| SCHEMBL7477288 | 0.72 | GRIA1 (0.41) | GRIA2GRIA1GRIA3GRIA4OPRL1 | |
| SCHEMBL7474858 | 0.70 | GRIA1 (0.44) | GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL7894069 | 0.70 | GRIA2 (0.39) | GRIA2GRIA1GRIA3NPY5RGRIA4 | |
| SCHEMBL7473870 | 0.68 | NPY5R (0.38) | GRIA2GRIA1GRIA3NPY5RGRIA4 | |
| SCHEMBL7469005 | 0.67 | GRIA1 (0.52) | GRIA2GRIA1GRIA3GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0937708-B1 | Sulphonamide derivatives | LILLY CO ELI (US) | 2002-12-18 | — | — | EP | disclosed |
| US-6362230-B1 | ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY | 2002-03-26 | — | — | US | disclosed |
| EP-0937708-A2 | sulphonamide derivatives | ELI LILLY AND COMPANY (US) | 1999-08-25 | — | — | EP | disclosed |