Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 16/20 | 0.48 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7606978 | 0.89 | CRHR1 (0.59) | CRHR1 | |
| SCHEMBL6202370 | 0.85 | CRHR1 (0.51) | CRHR1 | |
| SCHEMBL7476944 | 0.85 | CRHR1 (0.60) | CRHR1 | |
| SCHEMBL7474786 | 0.83 | CRHR1 (0.63) | CRHR1TLR8TLR7 | |
| SCHEMBL7481401 | 0.80 | CRHR1 (0.65) | CRHR1TLR7 | |
| SCHEMBL5404399 | 0.80 | CRHR1 (0.72) | CRHR1 | |
| SCHEMBL7474850 | 0.80 | CRHR1 (0.46) | CRHR1TLR8TLR7 | |
| SCHEMBL6204988 | 0.80 | CRHR1 (0.60) | CRHR1TLR8TLR7 | |
| SCHEMBL7477860 | 0.79 | CRHR1 (0.53) | CRHR1 | |
| SCHEMBL7479379 | 0.79 | CRHR1 (0.57) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255740-A2 | SUBSTITUTED ARYLPYRAZINES | NEUROGEN CORPORATION (US) | 2002-11-13 | — | — | EP | claimed |
| WO-2001060806-A2 | SUBSTITUTED ARYLPYRAZINES | NEUROGEN CORPORATION (US) | 2001-08-23 | — | — | WO | claimed |