Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | NCEH1 | Q6PIU2 | 4/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.39 |
| ▸ | PRNP | P04156 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7468694 | 0.84 | TDP1 (0.62) | POLBTDP1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL8474945 | 0.83 | POLB (0.47) | POLBTDP1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL10393003 | 0.80 | POLB (0.44) | POLBRAB9ASMN1; SMN2MAPTNPC1 | |
| SCHEMBL27480626 | 0.79 | TSHR (0.46) | TDP1RAB9ANCEH1MTNR1AHPGD | |
| SCHEMBL18049834 | 0.79 | SMN1; SMN2 (0.49) | POLBTDP1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL66670 | 0.78 | TDP1 (0.69) | TDP1MAPTMTNR1AHPGDHTT | |
| SCHEMBL596646 | 0.77 | POLB (0.57) | POLBTDP1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL7399435 | 0.77 | POLB (0.48) | POLBTDP1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL628771 | 0.77 | ERN1 (0.53) | TDP1RAB9ASMN1; SMN2MAPTNPC1 | |
| SCHEMBL28754118 | 0.77 | TDP1 (0.67) | TDP1MAPTMTNR1AHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077701-A4 | ANTI-VIRAL COMPOUNDS | LILLY CO ELI (US) | 2002-03-20 | — | — | EP | disclosed |
| US-6358971-B1 | FOR INHIBITING THE GROWTH OF A PICORNAVIRUS | ELI LILLY AND COMPANY | 2002-03-19 | — | — | US | disclosed |
| EP-1077701-A1 | ANTI-VIRAL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999059587-A1 | ANTI-VIRAL COMPOUNDS | ELI LILLY AND COMPANY (US) | 1999-11-25 | — | — | WO | disclosed |