Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 9/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 4/20 | 0.35 |
| ▸ | BCHE | P06276 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7478779 | 0.88 | CRHR1 (0.44) | CRHR1TLR7TLR8ACHEBCHE | |
| SCHEMBL5406607 | 0.82 | CRHR1 (0.68) | CRHR1 | |
| SCHEMBL6202450 | 0.80 | CRHR1 (0.56) | CRHR1TLR7 | |
| SCHEMBL7474607 | 0.79 | CRHR1 (0.60) | CRHR1 | |
| SCHEMBL7475201 | 0.79 | CRHR1 (0.68) | CRHR1 | |
| SCHEMBL7482544 | 0.78 | CRHR1 (0.52) | CRHR1TLR7TLR8 | |
| SCHEMBL7472049 | 0.78 | CRHR1 (0.56) | CRHR1TLR7 | |
| SCHEMBL6204586 | 0.77 | USP8 (0.43) | CRHR1TLR7ACHEBCHEALDH1A1 | |
| SCHEMBL6200464 | 0.77 | TLR7 (0.42) | CRHR1TLR7TLR8ALDH1A1 | |
| SCHEMBL7119050 | 0.77 | CRHR1 (0.48) | CRHR1TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255740-A2 | SUBSTITUTED ARYLPYRAZINES | NEUROGEN CORPORATION (US) | 2002-11-13 | — | — | EP | claimed |
| WO-2001060806-A2 | SUBSTITUTED ARYLPYRAZINES | NEUROGEN CORPORATION (US) | 2001-08-23 | — | — | WO | claimed |