Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.62 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.52 |
| ▸ | GPR183 | P32249 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7478156 | 0.82 | CHRNA7 (0.42) | CHRNA7KMT2ANPC1MEN1HTR1A | |
| SCHEMBL7478927 | 0.82 | HRH3 (0.56) | CHRNA7REV1 | |
| SCHEMBL7483471 | 0.81 | CHRNA7 (0.44) | CHRNA7NPC1PDE4BKDM4EUSP2 | |
| SCHEMBL3041638 | 0.81 | REV1 (0.74) | CHRNA7REV1KMT2APDE4BABCB1 | |
| Hydrochloric Acid SCHEMBL7480209 | 0.81 | CHRNA7 (0.44) | CHRNA7KMT2AMEN1PDE4BKDM4E | |
| SCHEMBL7476993 | 0.79 | DRD3 (0.52) | KMT2AMEN1PDE4BKDM4E | |
| SCHEMBL7478486 | 0.79 | KMT2A (0.47) | KMT2AMEN1PDE4BHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL7474283 | 0.78 | DRD3 (0.51) | KMT2AMEN1PDE4BKDM4E | |
| SCHEMBL7475383 | 0.77 | KMT2A (0.46) | CHRNA7REV1KMT2ANPC1MEN1 | |
| SCHEMBL21255938 | 0.77 | CHRNA7 (1.00) | CHRNA7REV1GPR183KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0950056-B1 | N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS | AVENTIS PHARMA INC (US) | 2002-09-18 | — | — | EP | disclosed |
| US-6004977-A | ANTIDEPRESSANTS, COGNITION ACTIVATORS, AND ALZHEIMER'S DISEASE TREATMENT | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-21 | — | — | US | disclosed |
| EP-0950056-A2 | N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS | HOECHST MARION ROUSSEL, INC. (US) | 1999-10-20 | — | — | EP | disclosed |
| WO-1998029407-A2 | N-(PYRIDINYLAMINO)ISOINDOLINES FOR TREATING ALZHEIMER'S AND DEPRESSION | HOECHST MARION ROUSSEL, INC. (US) | 1998-07-09 | — | — | WO | disclosed |