SCHEMBL7478486

SCHEMBL7478486

COc1cc2c(cc1F)CCN(Nc1ccncc1)C2

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.47
MEN1 O00255 2/20 0.47
MAOB P27338 4/20 0.42
MAOA P21397 2/20 0.40
SLC6A4 P31645 1/20 0.40
PDE4B Q07343 2/20 0.40
ALDH1A1 P00352 1/20 0.40
HCRTR2 O43614 1/20 0.39
ATM Q13315 1/20 0.39
ABCB1 P08183 2/20 0.39
DRD4 P21917 1/20 0.38
DRD3 P35462 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
GAA P10253 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
THRB P10828 1/20 0.38
HTR2C P28335 1/20 0.37
HTR2B P41595 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7476993 0.85 DRD3 (0.52) KMT2AMEN1PDE4BHCRTR2DRD4
Hydrochloric Acid SCHEMBL7474283 0.84 DRD3 (0.51) KMT2AMEN1MAOAPDE4BHCRTR2
SCHEMBL7484532 0.83 KMT2A (0.42) KMT2AMEN1MAOBMAOAPDE4B
SCHEMBL7489287 0.81 MEN1 (0.34) KMT2AMEN1ABCB1DRD4DRD3
Bromide SCHEMBL7484876 0.80 CYP17A1 (0.34) KMT2AMEN1ABCB1DRD4DRD3
SCHEMBL7475137 0.80 KMT2A (0.53) KMT2AMEN1MAOBMAOAPDE4B
SCHEMBL7477389 0.80 KMT2A (0.53) KMT2AMEN1MAOBMAOAPDE4B
SCHEMBL7477683 0.79 CHRNA7 (0.62) KMT2AMEN1PDE4BALDH1A1ABCB1
SCHEMBL7483483 0.79 DRD3 (0.48) KMT2AMEN1PDE4BHCRTR2DRD4
SCHEMBL7485133 0.79 DRD1 (0.48) DRD4DRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0950056-B1 N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS AVENTIS PHARMA INC (US) 2002-09-18 EP claimed
EP-0950056-A2 N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS HOECHST MARION ROUSSEL, INC. (US) 1999-10-20 EP claimed
WO-1998029407-A2 N-(PYRIDINYLAMINO)ISOINDOLINES FOR TREATING ALZHEIMER'S AND DEPRESSION HOECHST MARION ROUSSEL, INC. (US) 1998-07-09 WO claimed
EP-0950056-B1 N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS AVENTIS PHARMA INC (US) 2002-09-18 EP disclosed
US-6004977-A ANTIDEPRESSANTS, COGNITION ACTIVATORS, AND ALZHEIMER'S DISEASE TREATMENT HOECHST MARION ROUSSEL, INC. (US) 1999-12-21 US disclosed
EP-0950056-A2 N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS HOECHST MARION ROUSSEL, INC. (US) 1999-10-20 EP disclosed
WO-1998029407-A2 N-(PYRIDINYLAMINO)ISOINDOLINES FOR TREATING ALZHEIMER'S AND DEPRESSION HOECHST MARION ROUSSEL, INC. (US) 1998-07-09 WO disclosed