Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 3/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.43 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | TOP2A | P11388 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7485838 | 1.00 | PDE4D (0.43) | PDE4DPDE4BPDE4APDE4CNPBWR1 | |
| SCHEMBL7484622 | 0.86 | BRD4 (0.34) | — | |
| SCHEMBL7479960 | 0.82 | EED (0.45) | PDE4DPDE4BPDE4APDE4CNPBWR1 | |
| SCHEMBL7478753 | 0.82 | EED (0.45) | PDE4DPDE4BPDE4APDE4CNPBWR1 | |
| SCHEMBL7484260 | 0.82 | CHEK2 (0.45) | PDE4DPDE4BPDE4APDE4CNPBWR1 | |
| SCHEMBL7484268 | 0.82 | CHEK2 (0.45) | PDE4DPDE4BPDE4APDE4CNPBWR1 | |
| SCHEMBL7487767 | 0.79 | TLR9 (0.34) | — | |
| SCHEMBL7478776 | 0.79 | PIK3R1 (0.32) | — | |
| SCHEMBL7486430 | 0.79 | CHEK2 (0.53) | PDE4DPDE4BPDE4APDE4CNPBWR1 | |
| SCHEMBL7481361 | 0.78 | TBK1 (0.41) | PDE4DPDE4BPDE4APDE4CGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865281-B1 | NAPHTHYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ANTICOAGULANTS | BERLEX LAB (US) | 2002-04-03 | — | — | EP | disclosed |
| US-5849759-A | Naphthyl-substituted benzimidazole derivatives as anti-coagulants | BERLEX LABORATORIES, INC. (US) | 1998-12-15 | — | — | US | disclosed |