Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R1 | P27986 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 5/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.31 |
| ▸ | BRD4 | O60885 | 4/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.30 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.30 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7487767 | 0.95 | TLR9 (0.34) | PIK3R1PIK3CATLR9NR1H2NR1H3 | |
| SCHEMBL7484622 | 0.92 | BRD4 (0.34) | PIK3R1PIK3CANR1H2NR1H3BRD4 | |
| SCHEMBL7489186 | 0.84 | NR1H2 (0.36) | TLR9NR1H2NR1H3BRD4GABRG2 | |
| SCHEMBL7477789 | 0.79 | PDE4D (0.43) | — | |
| SCHEMBL7485838 | 0.79 | PDE4D (0.43) | — | |
| SCHEMBL7483264 | 0.76 | KDM4E (0.38) | NR1H2BRD4GABRG2GABRB3GABRA5 | |
| SCHEMBL862090 | 0.74 | PIK3R1 (0.37) | PIK3R1PIK3CANR1H2NR1H3GABRG2 | |
| SCHEMBL7475252 | 0.74 | KDM4E (0.38) | TLR9NR1H2BRD4GABRG2GABRB3 | |
| SCHEMBL7480954 | 0.74 | ESR2 (0.41) | NR1H2NR1H3BRD4GABRG2GABRB3 | |
| SCHEMBL30847402 | 0.73 | USP30 (0.39) | PIK3R1PIK3CANR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865281-B1 | NAPHTHYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ANTICOAGULANTS | BERLEX LAB (US) | 2002-04-03 | — | — | EP | disclosed |
| US-5849759-A | Naphthyl-substituted benzimidazole derivatives as anti-coagulants | BERLEX LABORATORIES, INC. (US) | 1998-12-15 | — | — | US | disclosed |