Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 8/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7472297 | 0.85 | PDE2A (0.54) | PDE2AGSK3BKDM4EALDH1A1HPGD | |
| SCHEMBL7478651 | 0.82 | PDE2A (0.58) | PDE2AKIF11KDM4EALDH1A1HPGD | |
| SCHEMBL20474139 | 0.81 | PDE2A (0.61) | PDE2AKIF11EPHX1GAA | |
| SCHEMBL18097879 | 0.80 | PDE2A (0.53) | PDE2AGSK3BGAA | |
| SCHEMBL7471753 | 0.80 | CES2 (0.49) | ALDH1A1CES2IDO1KCNN4 | |
| SCHEMBL2738655 | 0.78 | PDE2A (0.51) | PDE2AKIF11KDM4EALDH1A1HPGD | |
| SCHEMBL14720840 | 0.78 | DGAT1 (0.53) | KDM4EALDH1A1GAA | |
| SCHEMBL18172071 | 0.77 | PDE2A (0.49) | PDE2AKIF11KDM4EALDH1A1HPGD | |
| SCHEMBL20791346 | 0.75 | PDE2A (0.54) | PDE2AKIF11KDM4EALDH1A1HPGD | |
| SCHEMBL30525047 | 0.75 | PDE2A (0.54) | PDE2AKIF11KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077701-A4 | ANTI-VIRAL COMPOUNDS | LILLY CO ELI (US) | 2002-03-20 | — | — | EP | disclosed |
| US-6358971-B1 | FOR INHIBITING THE GROWTH OF A PICORNAVIRUS | ELI LILLY AND COMPANY | 2002-03-19 | — | — | US | disclosed |
| EP-1077701-A1 | ANTI-VIRAL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999059587-A1 | ANTI-VIRAL COMPOUNDS | ELI LILLY AND COMPANY (US) | 1999-11-25 | — | — | WO | disclosed |