Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 2/20 | 0.62 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.62 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.61 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.61 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.61 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.61 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8437904 | 0.84 | CHRNB2 (0.84) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNB1 | |
| SCHEMBL7408254 | 0.83 | CHRNA3 (0.61) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNB1 | |
| Hydrochloric Acid SCHEMBL7463532 | 0.83 | CHRNB2 (0.82) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNB1 | |
| Hydrochloric Acid SCHEMBL7409493 | 0.82 | CHRNB2 (0.63) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNB1 | |
| Hydrochloric Acid SCHEMBL7462725 | 0.81 | CHRNB2 (0.45) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNB1 | |
| SCHEMBL7411211 | 0.79 | CHRNB2 (0.51) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNB1 | |
| SCHEMBL18092147 | 0.77 | CHRNB2 (0.97) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNB1 | |
| SCHEMBL7368969 | 0.76 | CHRNB4 (1.00) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNB1 | |
| Hydrochloric Acid SCHEMBL8437647 | 0.76 | CHRNB4 (0.97) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNB1 | |
| Hydrochloric Acid SCHEMBL8437748 | 0.75 | CHRNB4 (0.97) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0950057-B1 | 3-PYRIDYL ENANTIOMERS AND THEIR USE AS ANALGESICS | ABBOTT LAB (US) | 2002-11-13 | — | — | EP | claimed |
| EP-0950057-B1 | 3-PYRIDYL ENANTIOMERS AND THEIR USE AS ANALGESICS | ABBOTT LAB (US) | 2002-11-13 | — | — | EP | disclosed |