Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | VCP | P55072 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.34 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.34 |
| ▸ | CASP6 | P55212 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7473891 | 0.85 | MAPK14 (0.52) | ALOX15MAP2K4MAPK14ALPLHSD17B1 | |
| SCHEMBL7479297 | 0.83 | MAPK14 (0.54) | ALOX15MAP2K4MAPK14 | |
| Hydrochloric Acid SCHEMBL7483144 | 0.82 | MAPK14 (0.53) | ALOX15MAP2K4MAPK14 | |
| SCHEMBL7474793 | 0.80 | ALOX15 (0.44) | ALOX15MAP2K4MAPK14ALPLHSD17B1 | |
| SCHEMBL7464576 | 0.80 | ALOX15 (0.47) | ALOX15MAP2K4MAPK14ALPLHSD17B1 | |
| SCHEMBL7811737 | 0.79 | MAPK14 (0.55) | ALOX15MAP2K4MAPK14ALPLHSD17B1 | |
| SCHEMBL7480688 | 0.79 | ALOX15 (0.43) | ALOX15MAP2K4MAPK14ALPLHSD17B1 | |
| Hydrochloric Acid SCHEMBL7478650 | 0.75 | DOT1L (0.46) | ALOX15NAMPTKDM4EALDH1A1ALPL | |
| SCHEMBL7478407 | 0.75 | MAPK14 (0.39) | ALOX15MAPK14ALPL | |
| SCHEMBL7481210 | 0.75 | PTAFR (0.42) | ALOX15MAPK14NAMPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218346-A1 | PYRAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021591-A1 | PYRAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-03-29 | — | — | WO | disclosed |
| EP-1075467-A1 | PYRAZOLE DERIVATIVES AS P-38 MAP KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-02-14 | — | — | EP | disclosed |
| WO-1999057101-A1 | PYRAZOLE DERIVATIVES AS P-38 MAP KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1999-11-11 | — | — | WO | disclosed |