Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | UNG | P13051 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 3/20 | 0.37 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.37 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.37 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.36 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.35 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | ACVR2B | Q13705 | 1/20 | 0.34 |
| ▸ | MYLK | Q15746 | 1/20 | 0.34 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.34 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7464576 | 0.84 | ALOX15 (0.47) | ALOX15ALPLHSD17B1HSD17B2MAP2K4 | |
| SCHEMBL7474793 | 0.84 | ALOX15 (0.44) | ALOX15ALPLHSD17B1HSD17B2MAP2K4 | |
| SCHEMBL7473891 | 0.81 | MAPK14 (0.52) | ALOX15ALPLHSD17B1HSD17B2MAP2K4 | |
| SCHEMBL7479297 | 0.79 | MAPK14 (0.54) | ALOX15MAP2K4MAPK14KCNH2HDAC1 | |
| SCHEMBL7478102 | 0.79 | ALOX15 (0.40) | ALOX15ALPLHSD17B1HSD17B2MAP2K4 | |
| Hydrochloric Acid SCHEMBL7483144 | 0.79 | MAPK14 (0.53) | ALOX15MAP2K4MAPK14KCNH2HDAC1 | |
| SCHEMBL1385137 | 0.78 | ALOX15 (0.39) | ALOX15ALPLHSD17B1HSD17B2MAP2K4 | |
| SCHEMBL7481210 | 0.77 | PTAFR (0.42) | ALOX15MAPK14HDAC2HDAC6 | |
| SCHEMBL7811737 | 0.77 | MAPK14 (0.55) | ALOX15ALPLHSD17B1HSD17B2MAP2K4 | |
| SCHEMBL7478407 | 0.77 | MAPK14 (0.39) | ALOX15ALPLABCC8KCNJ11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218346-A1 | PYRAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021591-A1 | PYRAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-03-29 | — | — | WO | disclosed |
| EP-1075467-A1 | PYRAZOLE DERIVATIVES AS P-38 MAP KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-02-14 | — | — | EP | disclosed |
| WO-1999057101-A1 | PYRAZOLE DERIVATIVES AS P-38 MAP KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1999-11-11 | — | — | WO | disclosed |