Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 3/20 | 0.36 |
| ▸ | VNN1 | O95497 | 2/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.34 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7479297 | 0.85 | MAPK14 (0.54) | MAPK14ALOX15KCNA5KCNH2 | |
| Hydrochloric Acid SCHEMBL7483144 | 0.85 | MAPK14 (0.53) | MAPK14ALOX15KCNA5KCNH2 | |
| SCHEMBL7481210 | 0.83 | PTAFR (0.42) | MAPK14ALOX15VNN1 | |
| SCHEMBL7478358 | 0.81 | MAP3K14 (0.40) | MAPK14ALOX15GRM5 | |
| SCHEMBL7473891 | 0.79 | MAPK14 (0.52) | MAPK14ALOX15ALPL | |
| SCHEMBL7464576 | 0.79 | ALOX15 (0.47) | MAPK14ALOX15KCNH2ABCC8KCNJ11 | |
| SCHEMBL7474793 | 0.79 | ALOX15 (0.44) | MAPK14ALOX15KCNH2ABCC8KCNJ11 | |
| SCHEMBL7480688 | 0.77 | ALOX15 (0.43) | MAPK14ALOX15KCNH2ABCC8KCNJ11 | |
| SCHEMBL7478102 | 0.75 | ALOX15 (0.40) | MAPK14ALOX15ALPL | |
| Hydrochloric Acid SCHEMBL7478650 | 0.74 | DOT1L (0.46) | ALOX15ALPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218346-A1 | PYRAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021591-A1 | PYRAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-03-29 | — | — | WO | disclosed |
| EP-1075467-A1 | PYRAZOLE DERIVATIVES AS P-38 MAP KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-02-14 | — | — | EP | disclosed |
| WO-1999057101-A1 | PYRAZOLE DERIVATIVES AS P-38 MAP KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1999-11-11 | — | — | WO | disclosed |