SCHEMBL7484532

SCHEMBL7484532

CN(C)C(=O)Oc1cc2c(cc1F)CCN(Nc1ccncc1)C2

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.42
MEN1 O00255 2/20 0.42
PDE4B Q07343 1/20 0.36
HCRTR2 O43614 1/20 0.36
ATM Q13315 1/20 0.35
DRD4 P21917 1/20 0.35
DRD3 P35462 1/20 0.35
KDM4E B2RXH2 2/20 0.34
HTR2C P28335 2/20 0.34
HTR2B P41595 2/20 0.34
THRB P10828 1/20 0.34
BCHE P06276 1/20 0.34
MAOA P21397 1/20 0.34
ACHE P22303 1/20 0.34
MAOB P27338 1/20 0.34
ALDH1A1 P00352 2/20 0.33
KCNH2 Q12809 1/20 0.33
TMEM97 Q5BJF2 1/20 0.33
SIGMAR1 Q99720 1/20 0.33
NPC1 O15118 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7477389 0.88 KMT2A (0.53) KMT2AMEN1PDE4BHCRTR2ATM
SCHEMBL7475137 0.88 KMT2A (0.53) KMT2AMEN1PDE4BHCRTR2ATM
SCHEMBL7478486 0.83 KMT2A (0.47) KMT2AMEN1PDE4BHCRTR2ATM
SCHEMBL7477425 0.83 ACHE (0.46) KMT2AMEN1BCHEACHENPSR1
SCHEMBL7484036 0.83 ACHE (0.43) KMT2AMEN1BCHEACHENPSR1
SCHEMBL7484538 0.82 KMT2A (0.39) KMT2AMEN1PDE4BHCRTR2ATM
SCHEMBL7478479 0.82 MEN1 (0.48) KMT2AMEN1PDE4BHCRTR2KDM4E
Hydrochloric Acid SCHEMBL7475937 0.82 MEN1 (0.47) KMT2AMEN1PDE4BHCRTR2DRD4
SCHEMBL7480200 0.79 ACHE (0.41) KDM4EBCHEMAOAACHEMAOB
SCHEMBL7477393 0.78 KMT2A (0.48) KMT2AMEN1PDE4BHCRTR2ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0950056-B1 N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS AVENTIS PHARMA INC (US) 2002-09-18 EP claimed
EP-0950056-A2 N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS HOECHST MARION ROUSSEL, INC. (US) 1999-10-20 EP claimed
WO-1998029407-A2 N-(PYRIDINYLAMINO)ISOINDOLINES FOR TREATING ALZHEIMER'S AND DEPRESSION HOECHST MARION ROUSSEL, INC. (US) 1998-07-09 WO claimed
EP-0950056-B1 N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS AVENTIS PHARMA INC (US) 2002-09-18 EP disclosed
US-6004977-A ANTIDEPRESSANTS, COGNITION ACTIVATORS, AND ALZHEIMER'S DISEASE TREATMENT HOECHST MARION ROUSSEL, INC. (US) 1999-12-21 US disclosed
EP-0950056-A2 N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS HOECHST MARION ROUSSEL, INC. (US) 1999-10-20 EP disclosed
WO-1998029407-A2 N-(PYRIDINYLAMINO)ISOINDOLINES FOR TREATING ALZHEIMER'S AND DEPRESSION HOECHST MARION ROUSSEL, INC. (US) 1998-07-09 WO disclosed