Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 8/20 | 0.52 |
| ▸ | CTSS | P25774 | 4/20 | 0.45 |
| ▸ | CTSK | P43235 | 3/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.41 |
| ▸ | CTSV | O60911 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7567924 | 0.86 | CTSL (0.54) | CTSLCTSSCTSKCTSBCTSV | |
| SCHEMBL5525342 | 0.84 | CTSL (0.60) | CTSLCTSSCTSKCTSBRAB9A | |
| SCHEMBL5525765 | 0.83 | CTSL (0.71) | CTSLCTSSCTSKCTSBEGLN2 | |
| SCHEMBL5530388 | 0.83 | CTSL (0.55) | CTSLCTSSCTSKCTSBCTSV | |
| SCHEMBL7477506 | 0.82 | CTSL (0.54) | CTSLCTSSCTSKCTSBEGLN2 | |
| SCHEMBL5534377 | 0.81 | CTSL (0.49) | CTSLCTSSCTSKCTSBCTSV | |
| SCHEMBL7561473 | 0.81 | CTSK (0.48) | CTSLCTSSCTSKCTSBCTSV | |
| SCHEMBL7562354 | 0.81 | CTSL (0.48) | CTSLCTSSCTSKCTSBCTSV | |
| SCHEMBL5528527 | 0.81 | CTSL (0.48) | CTSLCTSSCTSKCTSBCTSV | |
| SCHEMBL5526266 | 0.81 | CTSL (0.53) | CTSLCTSSCTSKCTSBCTSV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1178958-A2 | N-CYANOMETHYL AMIDES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2002-02-13 | — | — | EP | disclosed |
| WO-2000055125-A2 | N-CYANOMETHYL AMIDES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |