Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 7/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | PAK4 | O96013 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.48 |
| ▸ | MET | P08581 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | PRKACA | P17612 | 1/20 | 0.48 |
| ▸ | FLT1 | P17948 | 1/20 | 0.48 |
| ▸ | LTK | P29376 | 1/20 | 0.48 |
| ▸ | GRK5 | P34947 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7486328 | 0.92 | KMT2A (0.44) | PARP1AURKADAPK3JAK2PRKD3 | |
| SCHEMBL7482606 | 0.86 | MEN1 (0.56) | PARP1AURKADAPK3JAK2PRKD3 | |
| SCHEMBL7483064 | 0.84 | PARP1 (0.48) | PARP1AURKADAPK3JAK2PRKD3 | |
| SCHEMBL7479263 | 0.82 | MAPT (0.52) | PARP1DYRK1ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL7478020 | 0.79 | ALDH1A1 (0.45) | PARP1IGF1RPIM1CLK2GSK3A | |
| SCHEMBL7478856 | 0.76 | IP6K1 (0.41) | PARP1AURKADAPK3JAK2PRKD3 | |
| SCHEMBL7472669 | 0.75 | PARP1 (0.43) | PARP1PAK4PIM1GSK3BALK | |
| SCHEMBL7473258 | 0.75 | TYR (0.40) | PARP1PIM1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7477607 | 0.75 | PARP1 (0.43) | PARP1MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL7478026 | 0.74 | ADORA3 (0.45) | GSK3AGSK3BMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1005471-B1 | PYRAZOLO(3,4-D)PYRIMIDINES WITH ANTICONVULSIVE AND ANTIALLERGIC/ANTIASTHMATIC ACTION | DRESDEN ARZNEIMITTEL (DE) | 2002-09-04 | — | — | EP | claimed |
| EP-1005471-A1 | PYRAZOLO(3,4-D)PYRIMIDINES WITH ANTICONVULSIVE AND ANTIALLERGIC/ANTIASTHMATIC ACTION | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 2000-06-07 | — | — | EP | claimed |
| WO-1999067243-A1 | PYRAZOLO(3,4-D)PYRIMIDINES WITH ANTICONVULSIVE AND ANTIALLERGIC/ANTIASTHMATIC ACTION | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 1999-12-29 | — | — | WO | claimed |
| EP-1005471-B1 | PYRAZOLO(3,4-D)PYRIMIDINES WITH ANTICONVULSIVE AND ANTIALLERGIC/ANTIASTHMATIC ACTION | DRESDEN ARZNEIMITTEL (DE) | 2002-09-04 | — | — | EP | disclosed |
| US-6054460-A | Anticonvulsive and antiallergic/antiasthmatic pyrazolo-[3,4-d]pyrimidines, and process for preparing | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 2000-04-25 | — | — | US | disclosed |