Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.46 |
| ▸ | IP6K1 | Q92551 | 4/20 | 0.45 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.45 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.45 |
| ▸ | PNP | P00491 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7482606 | 0.84 | MEN1 (0.56) | MAPTIP6K1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL7478026 | 0.83 | ADORA3 (0.45) | MAPTADORA3KDM4ENPC1ALDH1A1 | |
| SCHEMBL7478856 | 0.82 | IP6K1 (0.41) | MAPTADORA3IP6K1IP6K3IP6K2 | |
| SCHEMBL7478583 | 0.82 | PARP1 (0.48) | MAPTIP6K1SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL7487274 | 0.81 | PARP1 (0.45) | MAPTSMN1; SMN2KDM4EALDH1A1PARP1 | |
| SCHEMBL7472669 | 0.81 | PARP1 (0.43) | MAPTIP6K1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7477607 | 0.81 | PARP1 (0.43) | MAPTIP6K1SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL7473258 | 0.81 | TYR (0.40) | MAPTADORA3IP6K1IP6K3IP6K2 | |
| SCHEMBL7483064 | 0.80 | PARP1 (0.48) | MAPTIP6K1SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL7482908 | 0.78 | PARP1 (0.47) | ADORA2AADORA1IP6K1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1005471-B1 | PYRAZOLO(3,4-D)PYRIMIDINES WITH ANTICONVULSIVE AND ANTIALLERGIC/ANTIASTHMATIC ACTION | DRESDEN ARZNEIMITTEL (DE) | 2002-09-04 | — | — | EP | claimed |
| EP-1005471-B1 | PYRAZOLO(3,4-D)PYRIMIDINES WITH ANTICONVULSIVE AND ANTIALLERGIC/ANTIASTHMATIC ACTION | DRESDEN ARZNEIMITTEL (DE) | 2002-09-04 | — | — | EP | disclosed |
| EP-1005471-A1 | PYRAZOLO(3,4-D)PYRIMIDINES WITH ANTICONVULSIVE AND ANTIALLERGIC/ANTIASTHMATIC ACTION | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 2000-06-07 | — | — | EP | disclosed |
| US-6054460-A | Anticonvulsive and antiallergic/antiasthmatic pyrazolo-[3,4-d]pyrimidines, and process for preparing | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 2000-04-25 | — | — | US | disclosed |
| WO-1999067243-A1 | PYRAZOLO(3,4-D)PYRIMIDINES WITH ANTICONVULSIVE AND ANTIALLERGIC/ANTIASTHMATIC ACTION | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 1999-12-29 | — | — | WO | disclosed |