Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | KCNQ3 | O43525 | 3/20 | 0.53 |
| ▸ | KCNQ2 | O43526 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.48 |
| ▸ | MDM4 | O15151 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.48 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.47 |
| ▸ | VNN1 | O95497 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.44 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31473447 | 0.96 | NAPRT (0.66) | NAPRTSMN1; SMN2GAAKCNQ3KCNQ2 | |
| SCHEMBL3383611 | 0.96 | NAPRT (0.66) | NAPRTSMN1; SMN2GAAKCNQ3KCNQ2 | |
| Hydrochloric Acid SCHEMBL7478603 | 0.93 | NAPRT (0.61) | NAPRTSMN1; SMN2GAAKCNQ3KCNQ2 | |
| SCHEMBL7440808 | 0.87 | NAPRT (0.72) | NAPRTSMN1; SMN2GAAKCNQ3KCNQ2 | |
| SCHEMBL18228607 | 0.84 | NAPRT (0.55) | NAPRTSMN1; SMN2GAAKCNQ3KCNQ2 | |
| SCHEMBL2475597 | 0.83 | NAPRT (0.62) | NAPRTSMN1; SMN2GAAKCNQ3KCNQ2 | |
| SCHEMBL17676098 | 0.80 | RAB9A (0.64) | NAPRTSMN1; SMN2GAAKCNQ3KCNQ2 | |
| SCHEMBL29457431 | 0.80 | NPC1 (0.62) | NAPRTSMN1; SMN2GAAKCNQ3KCNQ2 | |
| SCHEMBL5305773 | 0.80 | NAPRT (0.58) | NAPRTSMN1; SMN2GAAKCNQ3KCNQ2 | |
| SCHEMBL4467915 | 0.80 | NPC1 (0.62) | NAPRTSMN1; SMN2GAAKCNQ3KCNQ2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077701-A4 | ANTI-VIRAL COMPOUNDS | LILLY CO ELI (US) | 2002-03-20 | — | — | EP | disclosed |
| EP-1077701-A1 | ANTI-VIRAL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999059587-A1 | ANTI-VIRAL COMPOUNDS | ELI LILLY AND COMPANY (US) | 1999-11-25 | — | — | WO | disclosed |