Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MYC | P01106 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA7 | P43166 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | EED | O75530 | 1/20 | 0.35 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.35 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.35 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.35 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7475252 | 0.95 | KDM4E (0.38) | KDM4EMYCTSHRCA12CA1 | |
| SCHEMBL7489186 | 0.86 | NR1H2 (0.36) | KDM4ECA12CA9NR1H2GABRG2 | |
| SCHEMBL7478753 | 0.77 | EED (0.45) | EEDRBBP4SUZ12EZH2AEBP2 | |
| SCHEMBL7478776 | 0.76 | PIK3R1 (0.32) | NR1H2GABRG2GABRB3GABRA5BRD4 | |
| SCHEMBL3273621 | 0.76 | KDM4E (0.41) | KDM4ECA12CA1CA2CA7 | |
| SCHEMBL7480278 | 0.76 | NR1H2 (0.38) | KDM4EMYCTSHREEDRBBP4 | |
| SCHEMBL7480954 | 0.76 | ESR2 (0.41) | NR1H2GABRG2GABRB3GABRA5BRD4 | |
| SCHEMBL7479960 | 0.75 | EED (0.45) | EEDRBBP4SUZ12EZH2AEBP2 | |
| SCHEMBL7487767 | 0.74 | TLR9 (0.34) | NR1H2GABRG2GABRB3GABRA5BRD4 | |
| SCHEMBL862090 | 0.73 | PIK3R1 (0.37) | KDM4ENR1H2LMNAGAAGABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865281-B1 | NAPHTHYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ANTICOAGULANTS | BERLEX LAB (US) | 2002-04-03 | — | — | EP | disclosed |
| US-5849759-A | Naphthyl-substituted benzimidazole derivatives as anti-coagulants | BERLEX LABORATORIES, INC. (US) | 1998-12-15 | — | — | US | disclosed |