Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | XDH | P47989 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9742076 | 0.78 | ALDH1A1 (0.44) | ALDH1A1KDM4ELMNATSHRHSD17B10 | |
| SCHEMBL7475545 | 0.78 | KDM4E (0.42) | ALDH1A1KDM4ELMNATSHRHSD17B10 | |
| SCHEMBL7482128 | 0.71 | ALDH1A1 (0.38) | ALDH1A1KDM4ELMNATSHRHSD17B10 | |
| SCHEMBL7477781 | 0.71 | KDM4E (0.47) | ALDH1A1KDM4ELMNATSHRHSD17B10 | |
| SCHEMBL7479944 | 0.71 | ALDH1A1 (0.41) | ALDH1A1KDM4ELMNATSHRHSD17B10 | |
| SCHEMBL7479948 | 0.71 | ALDH1A1 (0.41) | ALDH1A1KDM4ELMNATSHRHSD17B10 | |
| SCHEMBL7476256 | 0.71 | KDM4E (0.41) | ALDH1A1KDM4ELMNATSHRHSD17B10 | |
| SCHEMBL7478732 | 0.70 | KDM4E (0.39) | ALDH1A1KDM4ELMNATSHRHSD17B10 | |
| SCHEMBL7478727 | 0.70 | KDM4E (0.39) | ALDH1A1KDM4ELMNATSHRHSD17B10 | |
| SCHEMBL7485703 | 0.70 | KDM4E (0.41) | ALDH1A1KDM4ELMNATSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0742218-B1 | PYRROLOPYRIDAZINE DERIVATIVE | SANKYO CO (JP) | 2002-12-04 | — | — | EP | disclosed |
| US-6063782-A | Pyrrolopyridazine derivatives | SANKYO COMPANY, LIMITED (JP) | 2000-05-16 | — | — | US | disclosed |
| EP-0742218-A1 | PYRROLOPYRIDAZINE DERIVATIVE | SANKYO COMPANY LIMITED (JP) | 1996-11-13 | — | — | EP | disclosed |