Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.49 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL222062 | 0.85 | MAPT (0.55) | MAPTTDP1PDE4DTUBB1MCL1 | |
| SCHEMBL7469868 | 0.83 | MAPT (0.58) | MAPTTDP1PDE4DTUBB1MCL1 | |
| SCHEMBL4299425 | 0.80 | MAPT (0.48) | MAPTTDP1PDE4DTUBB1MCL1 | |
| SCHEMBL9726919 | 0.80 | MAPT (0.58) | MAPTTDP1PDE4DTUBB1MCL1 | |
| SCHEMBL5159190 | 0.79 | MAPT (0.62) | MAPTTDP1PDE4DTUBB1MCL1 | |
| SCHEMBL4913002 | 0.79 | MAPT (0.56) | MAPTTDP1PDE4DTUBB1MCL1 | |
| SCHEMBL30069060 | 0.79 | ALDH1A1 (0.59) | MAPTTDP1PDE4DTUBB1MCL1 | |
| SCHEMBL1421887 | 0.79 | ALDH1A1 (0.59) | MAPTTDP1PDE4DTUBB1MCL1 | |
| SCHEMBL102827 | 0.79 | MAPT (0.72) | MAPTTDP1PDE4DTUBB1MEN1 | |
| SCHEMBL6932185 | 0.77 | MAPT (0.51) | MAPTTDP1PDE4DTUBB1MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1226139-A2 | CYCLIZED AMIDE DERIVATIVES FOR TREATING OR PREVENTING NEURONAL DAMAGE | Vertex Pharmaceuticals Incorporated (US) | 2002-07-31 | — | — | EP | disclosed |
| WO-2001002358-A2 | CYCLIZED AMIDE DERIVATIVES FOR TREATING OR PREVENTING NEURONAL DAMAGE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2001-01-11 | — | — | WO | disclosed |