Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.51 |
| ▸ | RET | P07949 | 4/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | CAPN9 | O14815 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | TGM2 | P21980 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6001054 | 0.84 | EGFR (0.64) | GSK3BRETPDGFRBJAK3CAPN9 | |
| SCHEMBL6001051 | 0.84 | EGFR (0.64) | GSK3BRETPDGFRBJAK3CAPN9 | |
| SCHEMBL28411784 | 0.74 | GSK3B (0.57) | GSK3BRETPDGFRBJAK3CAPN9 | |
| SCHEMBL6001027 | 0.71 | GSK3B (0.58) | GSK3BRETPDGFRBJAK3CAPN9 | |
| SCHEMBL6001026 | 0.71 | GSK3B (0.58) | GSK3BRETPDGFRBJAK3CAPN9 | |
| SCHEMBL7420392 | 0.71 | RET (0.69) | GSK3BRETPDGFRBJAK3CAPN9 | |
| 5-Nitroisatin SCHEMBL27856567 | 0.70 | CAPN9 (0.85) | GSK3BRETPDGFRBJAK3CAPN9 | |
| SCHEMBL3754352 | 0.69 | NOX4 (0.67) | GSK3BRETPDGFRBJAK3CAPN9 | |
| SCHEMBL3752053 | 0.69 | NOX4 (0.70) | GSK3BRETPDGFRBJAK3CAPN9 | |
| SCHEMBL5999635 | 0.69 | PDGFRB (0.55) | GSK3BRETPDGFRBJAK3CAPN9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0769947-A4 | INDOLINONE COMPOUNDS FOR THE TREATMENT OF DISEASE | SUGEN INC (US) | 1998-09-30 | — | — | EP | disclosed |
| EP-0769947-A1 | INDOLINONE COMPOUNDS FOR THE TREATMENT OF DISEASE | Sugen, Inc. (US) | 1997-05-02 | — | — | EP | disclosed |
| WO-1996040116-A1 | INDOLINONE COMPOUNDS FOR THE TREATMENT OF DISEASE | SUGEN, INC. (US) | 1996-12-19 | — | — | WO | disclosed |