Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.45 |
| ▸ | GPR52 | Q9Y2T5 | 2/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 1/20 | 0.42 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7515739 | 0.82 | MKNK1 (0.43) | GPR52ABHD6MKNK1MKNK2SMN1; SMN2 | |
| SCHEMBL7479263 | 0.81 | MAPT (0.52) | PARP1SMN1; SMN2MAPTKDM4EALDH1A1 | |
| SCHEMBL30606479 | 0.78 | KDR (0.42) | GPR52CDC7DBF4ALKMKNK1 | |
| SCHEMBL7482908 | 0.77 | PARP1 (0.47) | PARP1CDC7DBF4MKNK1MKNK2 | |
| SCHEMBL7483064 | 0.76 | PARP1 (0.48) | PARP1ALKSMN1; SMN2MAPTKDM4E | |
| SCHEMBL7478583 | 0.73 | PARP1 (0.48) | PARP1ALKSMN1; SMN2MAPTKDM4E | |
| SCHEMBL27866609 | 0.72 | ADORA2B (0.50) | CDC7DBF4ALK | |
| SCHEMBL7472669 | 0.72 | PARP1 (0.43) | PARP1ALKSMN1; SMN2MAPTKDM4E | |
| SCHEMBL7478026 | 0.71 | ADORA3 (0.45) | DAOMAPTKDM4EALDH1A1 | |
| SCHEMBL7486328 | 0.71 | KMT2A (0.44) | PARP1ALKSMN1; SMN2DAOMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1005471-B1 | PYRAZOLO(3,4-D)PYRIMIDINES WITH ANTICONVULSIVE AND ANTIALLERGIC/ANTIASTHMATIC ACTION | DRESDEN ARZNEIMITTEL (DE) | 2002-09-04 | — | — | EP | claimed |
| EP-1005471-A1 | PYRAZOLO(3,4-D)PYRIMIDINES WITH ANTICONVULSIVE AND ANTIALLERGIC/ANTIASTHMATIC ACTION | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 2000-06-07 | — | — | EP | claimed |
| WO-1999067243-A1 | PYRAZOLO(3,4-D)PYRIMIDINES WITH ANTICONVULSIVE AND ANTIALLERGIC/ANTIASTHMATIC ACTION | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 1999-12-29 | — | — | WO | claimed |
| EP-1005471-B1 | PYRAZOLO(3,4-D)PYRIMIDINES WITH ANTICONVULSIVE AND ANTIALLERGIC/ANTIASTHMATIC ACTION | DRESDEN ARZNEIMITTEL (DE) | 2002-09-04 | — | — | EP | disclosed |
| US-6054460-A | Anticonvulsive and antiallergic/antiasthmatic pyrazolo-[3,4-d]pyrimidines, and process for preparing | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 2000-04-25 | — | — | US | disclosed |