Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | QDPR | P09417 | 3/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.41 |
| ▸ | INPPL1 | O15357 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11524342 | 0.82 | HTR2C (0.56) | HTR2CSIGMAR1QDPRTLR9TLR7 | |
| SCHEMBL7394377 | 0.77 | HTR2C (0.60) | HTR2CSIGMAR1QDPR | |
| Hydrochloric Acid SCHEMBL4789235 | 0.76 | HTR2C (0.61) | HTR2CSIGMAR1QDPR | |
| SCHEMBL22085949 | 0.76 | MEN1 (0.46) | ADRA2AADRA2BADRA2C | |
| SCHEMBL4981424 | 0.72 | LTA4H (0.47) | — | |
| SCHEMBL6590672 | 0.72 | QDPR (0.54) | HTR2CSIGMAR1QDPRTLR9TLR7 | |
| SCHEMBL22391641 | 0.72 | INPPL1 (0.60) | HTR2CSIGMAR1INPPL1 | |
| SCHEMBL25717559 | 0.72 | INPPL1 (0.47) | HTR2CSIGMAR1QDPRTLR9TLR7 | |
| Hydrochloric Acid SCHEMBL30209303 | 0.71 | INPPL1 (0.59) | HTR2CSIGMAR1INPPL1 | |
| Hydrochloric Acid SCHEMBL26913755 | 0.71 | INPPL1 (0.59) | HTR2CSIGMAR1INPPL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0747357-B1 | Dihydropyridine NPY antagonists: piperidine derivatives | BRISTOL MYERS SQUIBB CO (US) | 2002-01-09 | — | — | EP | disclosed |
| US-5668151-A | USEFUL AS ANOREXIGENIC AGENTS IN PROMOTING WEIGHT LOSS AND TREATING EATING DISORDERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0747357-A2 | Dihydropyridine NPY antagonists: piperidine derivatives | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |