SCHEMBL7479734

SCHEMBL7479734

Nc1cccc2[nH]c(CN3CCCCC3)nc12

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 1/20 0.61
HPGD P15428 2/20 0.53
KDM4E B2RXH2 2/20 0.53
ALDH1A1 P00352 1/20 0.53
HSD17B10 Q99714 1/20 0.53
GRIN2B Q13224 6/20 0.49
CYP1A2 P05177 2/20 0.49
CYP2D6 P10635 2/20 0.49
CHEK1 O14757 1/20 0.46
PARP1 P09874 4/20 0.45
DRD4 P21917 4/20 0.43
MAPT P10636 2/20 0.42
MEN1 O00255 1/20 0.42
POLB P06746 1/20 0.42
GAA P10253 1/20 0.42
KMT2A Q03164 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
GRIN1 Q05586 1/20 0.41
DRD2 P14416 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7483052 0.99 HTT (0.58) HTTHPGDKDM4EALDH1A1HSD17B10
SCHEMBL6604643 0.86 HPGD (0.63) HTTHPGDKDM4EALDH1A1HSD17B10
SCHEMBL7474439 0.86 HTR6 (0.48) HTTHPGDGRIN2BCHEK1PARP1
SCHEMBL7476376 0.78 DRD4 (0.56) HTTHPGDKDM4EALDH1A1HSD17B10
SCHEMBL6994637 0.76 CHEK1 (0.56) ALDH1A1GRIN2BCHEK1PARP1MAPT
SCHEMBL15063202 0.76 HTT (1.00) HTTHPGDKDM4EALDH1A1HSD17B10
SCHEMBL22633621 0.76 HTT (1.00) HTTHPGDKDM4EALDH1A1HSD17B10
SCHEMBL31010306 0.76 HTT (1.00) HTTHPGDKDM4EALDH1A1HSD17B10
SCHEMBL7473327 0.76 DRD4 (0.57) HTTHPGDKDM4EALDH1A1HSD17B10
SCHEMBL5736933 0.75 CHEK1 (0.55) HPGDKDM4EALDH1A1HSD17B10GRIN2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6316482-B1 FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-11-13 US disclosed
US-6207693-B1 Benzamide derivatives having a vasopressin antagonistic activity FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-03-27 US disclosed
EP-0946519-A1 BENZAMIDE DERIVATIVES HAVING A VASOPRESSIN ANTAGONISTIC ACTIVITY FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-10-06 EP disclosed
WO-1998024771-A1 BENZAMIDE DERIVATIVES HAVING A VASOPRESSIN ANTAGONISTIC ACTIVITY FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-06-11 WO disclosed