Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | ATP4A | P20648 | 1/20 | 0.37 |
| ▸ | ATP4B | P51164 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6994637 | 0.87 | CHEK1 (0.56) | CHEK1GAAMAPTMEN1POLB | |
| SCHEMBL8599171 | 0.84 | CHEK1 (0.61) | CHEK1GAAMAPTMEN1POLB | |
| SCHEMBL3938941 | 0.84 | CHEK1 (0.57) | CHEK1GAAMAPTMEN1POLB | |
| SCHEMBL7964155 | 0.81 | CHEK1 (0.58) | CHEK1GAAMAPTMEN1POLB | |
| SCHEMBL7409334 | 0.80 | MGAM (0.49) | GAATDP1ALDH1A1ATP4AATP4B | |
| SCHEMBL4270442 | 0.80 | EGLN1 (0.42) | CHEK1GAAMAPTMEN1POLB | |
| SCHEMBL38663405 | 0.80 | BACE1 (0.38) | CHEK1GAANPC1ALDH1A1RAB9A | |
| SCHEMBL5738314 | 0.80 | PSMB8 (0.51) | CHEK1GAAL3MBTL1NPC1RAB9A | |
| SCHEMBL7479051 | 0.80 | CHEK1 (0.53) | CHEK1GAAMAPTMEN1POLB | |
| SCHEMBL3790024 | 0.80 | GAA (0.58) | CHEK1GAAMAPTMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1176959-B1 | NOVEL PROLINES AS ANTIMICROBIAL AGENTS | MERCK & CO INC (US) | 2006-03-08 | — | — | EP | disclosed |
| US-6579894-B2 | Bactericides, fungicides | MERCK & CO., INC. | 2003-06-17 | — | — | US | disclosed |
| EP-1176959-A4 | NOVEL PROLINES AS ANTIMICROBIAL AGENTS | MERCK & CO INC (US) | 2002-10-09 | — | — | EP | disclosed |
| US-6417217-B1 | TREATING INFECTIONS WITH HETEROCYCLIC MICROBIOCIDES THIS INVENTION RELATES TO THE FIELD OF TRANSFER RIBONUCLEIC ACID (TRNA) SYNTHETASE INHIBITORS, THEIR PREPARATION AND THEIR USE AS ANTIMICROBIAL ADMINISTERING TO THE SUBJECT A | MERCK & CO., INC. | 2002-07-09 | — | — | US | disclosed |
| EP-1176959-A1 | NOVEL PROLINES AS ANTIMICROBIAL AGENTS | Merck & Co., Inc. (US) | 2002-02-06 | — | — | EP | disclosed |
| US-6333344-B1 | ENZYME INHIBITORS AND BACTERICIDES | MERCK & CO. | 2001-12-25 | — | — | US | disclosed |
| WO-2000066119-A1 | NOVEL PROLINES AS ANTIMICROBIAL AGENTS | MERCK & CO., INC. (US) | 2000-11-09 | — | — | WO | disclosed |