Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 3/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | MMP1 | P03956 | 7/20 | 0.46 |
| ▸ | MMP2 | P08253 | 7/20 | 0.46 |
| ▸ | MMP9 | P14780 | 7/20 | 0.46 |
| ▸ | EGFR | P00533 | 5/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 2/20 | 0.42 |
| ▸ | TNKS | O95271 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7480044 | 1.00 | HDAC2 (0.50) | HDAC2HDAC3HDAC4HDAC1HDAC8 | |
| SCHEMBL7473991 | 0.91 | EGFR (0.49) | HDAC2HDAC1HDAC8HDAC6MMP1 | |
| SCHEMBL7473987 | 0.91 | EGFR (0.49) | HDAC2HDAC1HDAC8HDAC6MMP1 | |
| SCHEMBL7481722 | 0.88 | HDAC3 (0.52) | HDAC2HDAC3HDAC4HDAC1HDAC8 | |
| SCHEMBL7481721 | 0.88 | HDAC3 (0.52) | HDAC2HDAC3HDAC4HDAC1HDAC8 | |
| SCHEMBL7482423 | 0.82 | MEN1 (0.58) | KMT2AALDH1A1MAPTKDM4EHTT | |
| SCHEMBL7482416 | 0.82 | MEN1 (0.58) | KMT2AALDH1A1MAPTKDM4EHTT | |
| SCHEMBL7475111 | 0.82 | HTR1A (0.51) | KMT2AALDH1A1MAPTKDM4EHTT | |
| SCHEMBL17294167 | 0.74 | MMP9 (0.52) | MMP2MMP9ALDH1A1MAPTLMNA | |
| SCHEMBL7482004 | 0.74 | ALDH1A1 (0.46) | HDAC2HDAC3HDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6472396-B1 | Barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-29 | — | — | US | claimed |
| EP-0869947-B1 | BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-23 | — | — | EP | disclosed |