Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 6/20 | 0.36 |
| ▸ | JAK2 | O60674 | 5/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 2/20 | 0.32 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7481351 | 0.99 | TYK2 (0.35) | TYK2JAK2HTTMEN1KMT2A | |
| SCHEMBL7479802 | 0.81 | HDAC1 (0.31) | — | |
| SCHEMBL7480336 | 0.81 | KDM4E (0.44) | TYK2HTTMEN1KMT2AGAA | |
| Hydrochloric Acid SCHEMBL7490200 | 0.80 | KDM4E (0.43) | TYK2HTTGAAKCNMA1 | |
| SCHEMBL7481472 | 0.77 | GRIN2D (0.34) | MEN1KMT2A | |
| SCHEMBL7478752 | 0.75 | KCNMA1 (0.39) | TYK2JAK2MEN1KMT2APOLB | |
| Hydrochloric Acid SCHEMBL7483308 | 0.74 | KCNMA1 (0.38) | TYK2JAK2MEN1KMT2APOLB | |
| SCHEMBL7539760 | 0.74 | GAA (0.33) | TYK2JAK2HTTMEN1KMT2A | |
| SCHEMBL7481050 | 0.73 | KCNMA1 (0.35) | TYK2JAK2HTTMEN1KMT2A | |
| SCHEMBL7483392 | 0.72 | TYK2 (0.34) | TYK2JAK2MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0950056-B1 | N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS | AVENTIS PHARMA INC (US) | 2002-09-18 | — | — | EP | claimed |
| EP-0950056-A2 | N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS | HOECHST MARION ROUSSEL, INC. (US) | 1999-10-20 | — | — | EP | claimed |
| WO-1998029407-A2 | N-(PYRIDINYLAMINO)ISOINDOLINES FOR TREATING ALZHEIMER'S AND DEPRESSION | HOECHST MARION ROUSSEL, INC. (US) | 1998-07-09 | — | — | WO | claimed |