Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6742584 | 0.80 | KCNH2 (0.44) | HRH3HRH2HRH1KCNH2PGR | |
| SCHEMBL6738943 | 0.72 | KDM4E (0.55) | HRH3HRH2HRH1KCNH2GRIN1 | |
| SCHEMBL6619551 | 0.72 | KDM4E (0.55) | HRH3HRH2HRH1KCNH2GRIN1 | |
| SCHEMBL6623120 | 0.72 | KDM4E (0.55) | HRH3HRH2HRH1KCNH2GRIN1 | |
| Hydrochloric Acid SCHEMBL6621037 | 0.71 | KDM4E (0.54) | HRH3HRH2HRH1KCNH2GRIN1 | |
| SCHEMBL7471276 | 0.68 | HRH3 (0.41) | HRH3HRH1KCNH2 | |
| SCHEMBL6732773 | 0.67 | KCNH2 (0.42) | HRH3HRH2HRH1KCNH2GRIN1 | |
| SCHEMBL6738290 | 0.65 | THRB (0.43) | HRH3KCNH2 | |
| SCHEMBL6740295 | 0.65 | ALDH1A1 (0.43) | KCNH2CA1CA2CA9 | |
| SCHEMBL6738560 | 0.65 | HRH3 (0.42) | HRH3HRH2HRH1CHRNB2CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192157-A1 | BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000077000-A1 | NEW BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2000-12-21 | — | — | WO | disclosed |