Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 5/20 | 0.38 |
| ▸ | DRD3 | P35462 | 5/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6738290 | 0.82 | THRB (0.43) | HRH3THRBTSHRHSD17B10DRD2 | |
| SCHEMBL7036576 | 0.75 | KMT2A (0.57) | HRH3TSHRHSD17B10KCNH2MEN1 | |
| SCHEMBL7471272 | 0.71 | DRD2 (0.38) | THRBDRD2DRD3KCNH2 | |
| SCHEMBL6325206 | 0.69 | MEN1 (0.48) | HRH3TSHRHSD17B10DRD2DRD3 | |
| SCHEMBL6740295 | 0.68 | ALDH1A1 (0.43) | ARKCNH2ALDH1A1MAPT | |
| SCHEMBL7480893 | 0.68 | HRH3 (0.39) | HRH3HRH1KCNH2 | |
| SCHEMBL10410778 | 0.67 | FUCA1 (0.42) | DRD2MEN1KMT2AS1PR5 | |
| SCHEMBL6326862 | 0.67 | MEN1 (0.52) | HRH3THRBTSHRHSD17B10DRD2 | |
| SCHEMBL6326790 | 0.67 | MEN1 (0.52) | HRH3THRBTSHRHSD17B10DRD2 | |
| SCHEMBL6742584 | 0.66 | KCNH2 (0.44) | HRH3HSD17B10HRH1KCNH2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192157-A1 | BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000077000-A1 | NEW BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2000-12-21 | — | — | WO | disclosed |