Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | MMP1 | P03956 | 3/20 | 0.54 |
| ▸ | MMP3 | P08254 | 3/20 | 0.54 |
| ▸ | MMP7 | P09237 | 2/20 | 0.54 |
| ▸ | MMP9 | P14780 | 1/20 | 0.54 |
| ▸ | MMP13 | P45452 | 1/20 | 0.54 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.54 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HTR7 | P34969 | 2/20 | 0.53 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.52 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.52 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.52 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.52 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.52 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12162069 | 0.96 | NPC1 (0.60) | RAB9APAX8NPC1MMP1MMP3 | |
| SCHEMBL6325815 | 0.90 | RAB9A (0.59) | RAB9APAX8MMP1MMP3MMP7 | |
| SCHEMBL8211716 | 0.90 | RAB9A (0.59) | RAB9APAX8MMP1MMP3MMP7 | |
| SCHEMBL8207295 | 0.86 | MMP1 (0.61) | RAB9APAX8NPC1MMP1MMP3 | |
| SCHEMBL19011491 | 0.85 | PSEN1 (0.55) | RAB9APAX8HTR7PSEN1PSEN2 | |
| SCHEMBL21132496 | 0.85 | PSEN1 (0.55) | RAB9APAX8HTR7PSEN1PSEN2 | |
| SCHEMBL6977510 | 0.85 | MMP1 (0.63) | RAB9APAX8NPC1MMP1MMP3 | |
| SCHEMBL8211440 | 0.84 | RAB9A (0.56) | RAB9APAX8NPC1MMP1MMP3 | |
| SCHEMBL6323512 | 0.84 | RAB9A (0.56) | RAB9APAX8NPC1MMP1MMP3 | |
| SCHEMBL5805272 | 0.84 | HCRTR1 (0.55) | HCRTR1HCRTR2HTR7TMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0939629-A4 | THIOL SULFONAMIDE METALLOPROTEASE INHIBITORS | MONSANTO CO (US) | 2002-07-17 | — | — | EP | disclosed |
| EP-0939629-A1 | THIOL SULFONAMIDE METALLOPROTEASE INHIBITORS | MONSANTO COMPANY (US) | 1999-09-08 | — | — | EP | disclosed |
| WO-1998003166-A1 | THIOL SULFONAMIDE METALLOPROTEASE INHIBITORS | MONSANTO COMPANY (US) | 1998-01-29 | — | — | WO | disclosed |