Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.59 |
| ▸ | MMP1 | P03956 | 3/20 | 0.56 |
| ▸ | MMP3 | P08254 | 3/20 | 0.56 |
| ▸ | MMP7 | P09237 | 2/20 | 0.56 |
| ▸ | MMP9 | P14780 | 1/20 | 0.56 |
| ▸ | MMP13 | P45452 | 1/20 | 0.56 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.56 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | BRD4 | O60885 | 1/20 | 0.54 |
| ▸ | BRD2 | P25440 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8211716 | 1.00 | RAB9A (0.59) | RAB9APAX8MMP1MMP3MMP7 | |
| SCHEMBL8207295 | 0.96 | MMP1 (0.61) | RAB9APAX8MMP1MMP3MMP7 | |
| SCHEMBL6977510 | 0.95 | MMP1 (0.63) | RAB9APAX8MMP1MMP3MMP7 | |
| SCHEMBL7480895 | 0.90 | RAB9A (0.57) | RAB9APAX8MMP1MMP3MMP7 | |
| SCHEMBL6323512 | 0.86 | RAB9A (0.56) | RAB9APAX8MMP1MMP3MMP7 | |
| SCHEMBL8211440 | 0.86 | RAB9A (0.56) | RAB9APAX8MMP1MMP3MMP7 | |
| SCHEMBL12162069 | 0.86 | NPC1 (0.60) | RAB9APAX8MMP1MMP3MMP7 | |
| SCHEMBL2572076 | 0.85 | MEN1 (0.60) | RAB9AMMP1MMP3MMP7MMP13 | |
| SCHEMBL5885963 | 0.85 | BRD4 (0.57) | RAB9APAX8BRD4BRD2GAA | |
| SCHEMBL6302770 | 0.85 | BRD4 (0.57) | RAB9APAX8BRD4BRD2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050014840-A1 | Thiol sulfonamide metalloprotease inhibitors | PHARMACIA CORPORATION | 2005-01-20 | — | — | US | disclosed |
| US-6747027-B1 | SELECTIVELY INHIBITS IN VITRO ACTIVITY OF HUMAN MATRIX METALLOPROTEASE-13 OVER IN VITRO ACTIVITY OF HUMAN MATRIX METALLOPROTEASE-1 | PHARMACIA CORPORATION | 2004-06-08 | — | — | US | disclosed |
| CN-1238688-A | Thiol sulfonamide metalloprotease inhibitors | MONSANTO CO (US) | 1999-12-15 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014840-A1 | Thiol sulfonamide metalloprotease inhibitors | MMP12, MMP13, MMP3 | RAB9A 3653/4885PAX8 2579/4885MMP1 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.