Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 3/20 | 0.45 |
| ▸ | TUBB | P07437 | 3/20 | 0.45 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.45 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.45 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.45 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.45 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.45 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.45 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.45 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.45 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.45 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.45 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.45 |
| ▸ | TUBB2B | Q9BVA1 | 3/20 | 0.45 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.45 |
| ▸ | DHODH | Q02127 | 9/20 | 0.42 |
| ▸ | MDM4 | O15151 | 2/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6589916 | 0.92 | TUBB4A (0.44) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL6804460 | 0.82 | PARP1 (0.63) | DHODHPARP1CHEK2 | |
| SCHEMBL7474706 | 0.73 | PARP1 (0.48) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL6804468 | 0.69 | PARP1 (0.40) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL7859132 | 0.68 | PARP1 (0.52) | DHODHPARP1HPSECHEK2 | |
| SCHEMBL6588713 | 0.68 | HPSE (0.43) | DHODHPARP1HPSECHEK2 | |
| SCHEMBL7480353 | 0.68 | PARP1 (0.44) | DHODHPARP1HPSE | |
| SCHEMBL15519637 | 0.68 | DHODH (0.47) | DHODHPARP1HPSE | |
| SCHEMBL7853256 | 0.68 | PARP1 (0.65) | DHODHPARP1HPSE | |
| SCHEMBL6585185 | 0.67 | HPSE (0.44) | DHODHPARP1HPSECHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177178-A1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000068206-A1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2000-11-16 | — | — | WO | disclosed |