Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Silver. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28418723 | 0.93 | TSHR (0.44) | TSHRMEN1KMT2AALDH1A1CYP1A2 | |
| Nitroethane SCHEMBL8669596 | 0.84 | TSHR (0.69) | TSHRALDH1A1CYP1A2CYP2D6CYP2C9 | |
| Nitric Acid SCHEMBL28647494 | 0.84 | CA5A (0.50) | TSHRALDH1A1CYP1A2CYP2D6CYP2C9 | |
| Nitric Acid SCHEMBL15263924 | 0.84 | CA5A (0.50) | TSHRALDH1A1CYP1A2CYP2D6CYP2C9 | |
| Nitric Acid SCHEMBL724142 | 0.84 | CA5A (0.50) | TSHRALDH1A1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL8673072 | 0.77 | ALDH1A1 (0.52) | TSHRMEN1KMT2AALDH1A1CYP1A2 | |
| Silver SCHEMBL28326742 | 0.75 | TSHR (0.40) | TSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL30 | 0.73 | — | — | |
| SCHEMBL124190 | 0.73 | — | — | |
| SCHEMBL1736341 | 0.73 | ALDH1A1 (0.40) | TSHRMEN1KMT2AALDH1A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1202095-C | Heteroaromatic ring compounds | SUMITOMO PHARMA (JP) | 2005-05-18 | — | — | CN | disclosed |
| CN-1361770-A | Heteroaromatic ring compounds | SUMITOMO PHARMA (JP) | 2002-07-31 | — | — | CN | disclosed |
| EP-1201661-A1 | HETEROAROMATIC RING COMPOUNDS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2002-05-02 | — | — | EP | disclosed |