SCHEMBL748172

SCHEMBL748172

O=c1ccc2cnc(Nc3ccccn3)[nH]c-2n1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 6/20 0.46
KMT2A Q03164 6/20 0.46
NPC1 O15118 6/20 0.46
RAB9A P51151 6/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
ALDH1A1 P00352 2/20 0.46
HPGD P15428 1/20 0.46
ALOX15 P16050 1/20 0.46
PIM1 P11309 1/20 0.42
APAF1 O14727 1/20 0.42
TDP2 O95551 1/20 0.42
CDC25B P30305 1/20 0.42
CASP6 P55212 1/20 0.42
RCE1 Q9Y256 1/20 0.42
MAPK10 P53779 1/20 0.39
GFER P55789 1/20 0.39
TP53 P04637 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
GRM4 Q14833 2/20 0.37
L3MBTL1 Q9Y468 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2320860 0.77 PNP (0.46) MEN1KMT2ANPC1RAB9AHPGD
SCHEMBL5220362 0.70 MEN1 (0.51) MEN1KMT2ANPC1RAB9ASMN1; SMN2
SCHEMBL20400863 0.70 CFTR (0.42) MEN1KMT2ANPC1RAB9ASMN1; SMN2
SCHEMBL30719375 0.70 PIM1 (0.40) MEN1KMT2ANPC1RAB9ASMN1; SMN2
SCHEMBL4075886 0.67 SYK (0.46) MAPK10TP53
SCHEMBL5887078 0.66 NPC1 (0.41) KMT2ANPC1RAB9ASMN1; SMN2ALDH1A1
SCHEMBL15993522 0.65 SCD (0.39) KMT2ANPC1RAB9ASMN1; SMN2ALDH1A1
SCHEMBL221242 0.64 KMT2A (0.76) MEN1KMT2ANPC1RAB9ASMN1; SMN2
SCHEMBL29391624 0.64 KMT2A (0.76) MEN1KMT2ANPC1RAB9ASMN1; SMN2
SCHEMBL17343167 0.63 NPC1 (1.00) MEN1KMT2ANPC1RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 100 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150111896-A1 HEMATOPOIETIC PROTECTION AGAINST CHEMOTHERAPEUTIC COMPOUNDS USING SELECTIVE CYCLIN-DEPENDENT KINASE 4/6 INHIBITORS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2015-04-23 US claimed
US-20110224227-A1 HEMATOPOIETIC PROTECTION AGAINST CHEMOTHERAPEUTIC COMPOUNDS USING SELECTIVE CYCLIN-DEPENDENT KINASE 4/6 INHIBITORS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2011-09-15 US claimed
US-20110224221-A1 HEMATOPOIETIC PROTECTION AGAINST IONIZING RADIATION USING SELECTIVE CYCLIN-DEPENDENT KINASE 4/6 INHIBITORS NORTH CAROLINA AT CHAPEL HILL, THE UNIVERSITY OF 2011-09-15 US claimed
EP-2341906-A2 HEMATOPOIETIC PROTECTION AGAINST IONIZING RADIATION USING SELECTIVE CYCLIN-DEPENDENT KINASE 4/6 INHIBITORS The University of North Carolina At Chapel Hill (US) 2011-07-13 EP claimed
EP-2341911-A2 HEMATOPOIETIC PROTECTION AGAINST CHEMOTHERAPEUTIC COMPOUNDS USING SELECTIVE CYCLIN-DEPENDENT KINASE 4/6 INHIBITORS The University of North Carolina At Chapel Hill (US) 2011-07-13 EP claimed
WO-2010039997-A9 HEMATOPOIETIC PROTECTION AGAINST CHEMOTHERAPEUTIC COMPOUNDS USING SELECTIVE CYCLIN-DEPENDENT KINASE 4/6 INHIBITORS THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2011-05-05 WO claimed
WO-2010051127-A2 HEMATOPOIETIC PROTECTION AGAINST IONIZING RADIATION USING SELECTIVE CYCLIN-DEPENDENT KINASE 4/6 INHIBITORS THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2010-05-06 WO claimed
WO-2010039997-A2 HEMATOPOIETIC PROTECTION AGAINST CHEMOTHERAPEUTIC COMPOUNDS USING SELECTIVE CYCLIN-DEPENDENT KINASE 4/6 INHIBITORS THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2010-04-08 WO claimed
EP-3399026-B1 REPROGRAMMING OF CELLS TO A NEW FATE SCRIPPS RESEARCH INST (US) 2024-06-26 EP disclosed
US-20210189348-A1 REPROGRAMMING OF CELLS TO A NEW FATE THE SCRIPPS RESEARCH INSTITUTE 2021-06-24 US disclosed
US-10934528-B2 Reprogramming of cells to a new fate THE SCRIPPS RESEARCH INSTITUTE (US) 2021-03-02 US disclosed
EP-3718560-A2 CYCLIN DEPENDENT KINASE INHIBITORS AND METHODS OF USE The University of North Carolina at Chapel Hill (US) 2020-10-07 EP disclosed
EP-3406260-B1 CYCLIN DEPENDENT KINASE INHIBITORS AND METHODS OF USE UNIV NORTH CAROLINA CHAPEL HILL (US) 2020-09-23 EP disclosed
EP-3172214-B1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE DERIVATIVES AS CDK INHIBITORS AND USES THEREOF SUNSHINE LAKE PHARMA CO LTD (CN) 2020-05-13 EP disclosed
EP-1470124-A1 2-(PYRIDIN-2-YLAMINO)-PYRIDO 2,3-d]PYRIMIDIN-7-ONES Warner-Lambert Company LLC (US) 2004-10-27 EP disclosed
EP-1470124-A1 2-(PYRIDIN-2-YLAMINO)-PYRIDO 2,3-d]PYRIMIDIN-7-ONES Warner-Lambert Company LLC (US) 2004-10-27 EP disclosed
WO-2003062236-A8 2-(PYRIDIN-2-YLAMINO)-PYRIDO[2,3d]PYRIMIDIN-7-ONES WARNER LAMBERT CO (US) 2003-12-24 WO disclosed
US-20030149001-A1 2-(Pyridin-2-ylamino)-pyrido[2,3-d]pyrimidin-7-ones BARVIAN MARK (US) 2003-08-07 US disclosed
WO-2003062236-A1 2-(PYRIDIN-2-YLAMINO)-PYRIDO[2,3d]PYRIMIDIN-7-ONES WARNER-LAMBERT COMPANY LLC (US) 2003-07-31 WO disclosed
WO-2003062236-A1 2-(PYRIDIN-2-YLAMINO)-PYRIDO[2,3d]PYRIMIDIN-7-ONES WARNER-LAMBERT COMPANY LLC (US) 2003-07-31 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110224227-A1 HEMATOPOIETIC PROTECTION AGAINST CHEMOTHERAPEUTIC COMPOUNDS USING SELECTIVE CYCLIN-DEPENDENT KINASE 4/6 INHIBITORS CDK6, CDK4, CDKN1A MEN1 3244/4885KMT2A 436/4885NPC1 3845/4885
US-20110224221-A1 HEMATOPOIETIC PROTECTION AGAINST IONIZING RADIATION USING SELECTIVE CYCLIN-DEPENDENT KINASE 4/6 INHIBITORS CDK4, CDK6, CDKN1A MEN1 2750/4885KMT2A 459/4885NPC1 3691/4885
US-20030149001-A1 2-(Pyridin-2-ylamino)-pyrido[2,3-d]pyrimidin-7-ones CDK4, CDK2, CDK1 MEN1 2406/4885KMT2A 753/4885NPC1 3879/4885
US-20150111896-A1 HEMATOPOIETIC PROTECTION AGAINST CHEMOTHERAPEUTIC COMPOUNDS USING SELECTIVE CYCLIN-DEPENDENT KINASE 4/6 INHIBITORS CDK6, CDK4, CDKN1A MEN1 3244/4885KMT2A 436/4885NPC1 3845/4885
US-10934528-B2 Reprogramming of cells to a new fate ALPG, POU5F1, POU2F1 MEN1 2207/4885KMT2A 542/4885NPC1 3682/4885
US-20210189348-A1 REPROGRAMMING OF CELLS TO A NEW FATE ALPG, POU5F1, POU2F1 MEN1 2207/4885KMT2A 542/4885NPC1 3682/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.