Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 8/20 | 0.68 |
| ▸ | MMP9 | P14780 | 8/20 | 0.68 |
| ▸ | MMP3 | P08254 | 3/20 | 0.68 |
| ▸ | MMP8 | P22894 | 3/20 | 0.59 |
| ▸ | MMP13 | P45452 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | DGKA | P23743 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzene SCHEMBL11441206 | 0.76 | DGKA (0.77) | LMNADGKATSHRALDH1A1 | |
| Benzene SCHEMBL9957260 | 0.76 | DGKA (0.77) | LMNADGKATSHRALDH1A1 | |
| Cetyl Palmitate SCHEMBL8430810 | 0.74 | TSHR (0.60) | LMNADGKATSHRALDH1A1 | |
| O-Xylene SCHEMBL31519872 | 0.74 | DGKA (0.62) | LMNADGKATSHRALDH1A1 | |
| SCHEMBL9446511 | 0.73 | DGKA (0.57) | LMNADGKATSHRALDH1A1 | |
| SCHEMBL11123903 | 0.73 | ALDH1A1 (0.57) | LMNADGKATSHRALDH1A1 | |
| SCHEMBL7094905 | 0.73 | ALDH1A1 (0.57) | LMNADGKATSHRALDH1A1 | |
| SCHEMBL16215015 | 0.73 | DGKA (0.62) | LMNADGKATSHRALDH1A1 | |
| SCHEMBL12060084 | 0.73 | DGKA (0.61) | DGKATSHR | |
| SCHEMBL25243121 | 0.71 | DGKA (0.87) | LMNADGKATSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6472396-B1 | Barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-29 | — | — | US | disclosed |
| EP-0869947-B1 | BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-23 | — | — | EP | disclosed |
| US-6110924-A | MATRIX METALLOPROTEASE INHIBITORS | ROCHE DIAGNOSTICS GMBH (DE) | 2000-08-29 | — | — | US | disclosed |
| EP-0869947-A1 | NEW BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS | Roche Diagnostics GmbH (DE) | 1998-10-14 | — | — | EP | disclosed |
| WO-1997023465-A1 | NEW BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS | BOEHRINGER MANNHEIM GMBH (DE) | 1997-07-03 | — | — | WO | disclosed |