Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.33 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.32 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6332268 | 0.84 | BCHE (0.44) | BCHESLC6A2SLC6A4SLC6A3HTR1A | |
| Quinoline SCHEMBL28819404 | 0.75 | ALDH1A1 (0.68) | ALDH1A1TP53PDE10ACYP3A4MEN1 | |
| SCHEMBL21920702 | 0.74 | FNTA (0.33) | ALDH1A1SLC6A2SLC6A4SLC6A3HTR1A | |
| Quinoline SCHEMBL27309468 | 0.71 | ALDH1A1 (0.74) | ALDH1A1TP53SLC6A4HTR1APDE10A | |
| Quinoline SCHEMBL3629028 | 0.71 | ALDH1A1 (0.74) | ALDH1A1TP53SLC6A4HTR1APDE10A | |
| Quinoline SCHEMBL28274774 | 0.69 | ALDH1A1 (0.71) | ALDH1A1TP53SLC6A4HTR1ACYP3A4 | |
| Quinoline SCHEMBL28192494 | 0.69 | ALDH1A1 (0.71) | ALDH1A1TP53SLC6A4HTR1ACYP3A4 | |
| Quinoline SCHEMBL27478894 | 0.69 | ALDH1A1 (0.77) | ALDH1A1TP53PDE10ACYP3A4MEN1 | |
| SCHEMBL1917482 | 0.69 | BCHE (0.40) | BCHE | |
| Quinoline SCHEMBL27391761 | 0.69 | ALDH1A1 (0.94) | ALDH1A1TP53PDE10ACYP3A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1250334-A2 | AGENTS AND METHODS FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ELI LILLY AND COMPANY (US) | 2002-10-23 | — | — | EP | disclosed |
| EP-1242420-A2 | AGENTS AND METHODS FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ELI LILLY AND COMPANY (US) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001044235-A2 | AGENTS AND METHODS FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ELI LILLY AND COMPANY (US) | 2001-06-21 | — | — | WO | disclosed |
| WO-2001044247-A2 | AGENTS AND METHODS FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ELI LILLY AND COMPANY (US) | 2001-06-21 | — | — | WO | disclosed |