Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Quinoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.74 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | HTR3B | O95264 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinoline SCHEMBL27309468 | 1.00 | ALDH1A1 (0.74) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL28192494 | 0.98 | ALDH1A1 (0.71) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL28274774 | 0.98 | ALDH1A1 (0.71) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL27731962 | 0.92 | ALDH1A1 (0.63) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL27282295 | 0.92 | ALDH1A1 (0.68) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL20473420 | 0.92 | ALDH1A1 (0.68) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL28159418 | 0.91 | ALDH1A1 (0.74) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL27914505 | 0.91 | ALDH1A1 (0.61) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL28231211 | 0.91 | ALDH1A1 (0.61) | ALDH1A1NPC1POLBRAB9ACYP3A4 | |
| Quinoline SCHEMBL27553399 | 0.91 | ALDH1A1 (0.61) | ALDH1A1NPC1POLBRAB9ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 188 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112390751-A | Toll-like receptor-7 small molecule inhibitor and preparation method thereof | 清华大学 | 2021-02-23 | — | — | CN | claimed |
| CN-109384780-A | Tetrahydro-proto-berberine compounds, preparation method, purposes and pharmaceutical composition | 中国科学院上海药物研究所 | 2019-02-26 | — | — | CN | claimed |
| CN-104193609-B | 1, 4-naphthoquinone derivatives and therapeutic uses thereof | 国家科研中心 | 2017-04-12 | — | — | CN | claimed |
| CN-105294685-B | Hexahydropyrazine quinolines D3 receptors ligand and its production and use | 东南大学 | 2017-03-08 | — | — | CN | claimed |
| CN-105189506-A | Compounds and compositions for the treatment of parasitic diseases | NOVARTIS AG | 2015-12-23 | — | — | CN | claimed |
| CN-101272777-B | Stable dosage forms of spiro and dispiro 1,2, 4-trioxolane antimalarials | RANBAXY LAB LTD | 2013-01-30 | — | — | CN | claimed |
| CN-102558048-A | Polycrystal substance of piperaquine phosphate and preparation method thereof | ZHUHAI RUNDU PHARMACEUTICAL CO LTD | 2012-07-11 | — | — | CN | claimed |
| CN-101440063-B | Preparation of piperaquini phosphatis | CHONGQING KANGLE PHARMACEUTICAL CO LTD | 2011-07-13 | — | — | CN | claimed |
| CN-102015607-A | 1, 4-naphthoquinone derivatives and therapeutic uses thereof | CENTRE NAT RECH SCIENT | 2011-04-13 | — | — | CN | claimed |
| CN-101466680-A | Process for synthesizing piperazine-piperidine compounds | WYETH CORP (US) | 2009-06-24 | — | — | CN | claimed |
| CN-101440063-A | Preparation of piperaquini phosphatis | CHONGQING KANGLE PHARMACEUTICA (CN) | 2009-05-27 | — | — | CN | claimed |
| CN-100448051-C | Organic electroluminescence device | UNIV TSINGHUA (CN) | 2008-12-31 | — | — | CN | claimed |
| CN-101272777-A | Stable dosage forms of spiro and dispiro 1,2, 4-trioxolane antimalarials | RANBAXY LAB LTD (IN) | 2008-09-24 | — | — | CN | claimed |
| CN-1320001-C | Novel polyvinyl esters | CELANESE VENTURES GMBH (DE) | 2007-06-06 | — | — | CN | claimed |
| CN-1678645-A | Novel polyvinyl esters | CELANESE VENTURES GMBH (DE) | 2005-10-05 | — | — | CN | claimed |
| CN-1564641-A | Organic electroluminescence device | UNIV TSINGHUA (CN) | 2005-01-12 | — | — | CN | claimed |
| CN-1161002-C | Organic electroluminescent device | 清华大学 | 2004-08-04 | — | — | CN | claimed |
| CN-1457105-A | Organic electroluminescent device | UNIV TSINGHUA (CN) | 2003-11-19 | — | — | CN | claimed |
| CN-1035286-A | The amino acid derivative of renin-inhibiting | HOECHST AG (DE) | 1989-09-06 | — | — | CN | claimed |
| WO-2024049718-A3 | QUINOLINE PIPERAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITION AND USES THEREOF | IMMUNOCURE INC. (US) | 2024-04-04 | — | — | WO | disclosed |
| WO-2024049718-A2 | QUINOLINE PIPERAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITION AND USES THEREOF | IMMUNOCURE INC. (US) | 2024-03-07 | — | — | WO | disclosed |
| WO-2024049718-A2 | QUINOLINE PIPERAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITION AND USES THEREOF | IMMUNOCURE INC. (US) | 2024-03-07 | — | — | WO | disclosed |
| CN-116615428-A | Tricyclic pyridones and pyrimidinones | 医睿世康药业研发公司 | 2023-08-18 | — | — | CN | disclosed |
| EP-4217071-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | Erasca, Inc. (US) | 2023-08-02 | — | — | EP | disclosed |
| US-20230203063-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | ERASCA, INC. | 2023-06-29 | — | — | US | disclosed |
| CN-112390751-B | Toll-like receptor-7 small molecule inhibitor and preparation method thereof | 清华大学 | 2022-07-05 | — | — | CN | disclosed |
| US-20220119409-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | ERASCA, INC. | 2022-04-21 | — | — | US | disclosed |
| US-11279696-B2 | Processes for the preparation of 7-{4-[4-(1-benzothiophen-4-yl) piperazin-1-yl]butoxy}quinolin-2(1H)-one | MSN LABORATORIES PRIVATE LIMITED (IN) | 2022-03-22 | — | — | US | disclosed |
| CN-110606830-B | Method for producing piperaquine phosphate intermediate quinoline piperazine hydrochloride by applying piperazine | 珠海润都制药股份有限公司 | 2022-03-18 | — | — | CN | disclosed |
| WO-2021127404-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | ERASCA, INC. (US) | 2021-06-24 | — | — | WO | disclosed |
| CN-112390751-A | Toll-like receptor-7 small molecule inhibitor and preparation method thereof | 清华大学 | 2021-02-23 | — | — | CN | disclosed |
| WO-2020183011-A1 | HTR1D INHIBITORS AND USES THEREOF IN THE TREATMENT OF CANCER | INSTITUT CURIE (FR) | 2020-09-17 | — | — | WO | disclosed |
| CN-110606830-A | Method for producing piperaquine phosphate intermediate quinoline piperazine hydrochloride by applying piperazine | 珠海润都制药股份有限公司 | 2019-12-24 | — | — | CN | disclosed |
| CN-110536889-A | Atazanavir (ATV) analogs for the treatment of HIV infection | GILEAD SCIENCES INC | 2019-12-03 | — | — | CN | disclosed |
| CN-209696598-U | A kind of device recycling vacuum tail gas in triethyl orthoformate production process | FUSHUN SHUNTE CHEMICAL CO LTD | 2019-11-29 | — | — | CN | disclosed |
| CN-107405870-B | Laminated body, temporary bond composition and temporary bond film | 富士胶片株式会社 | 2019-11-19 | — | — | CN | disclosed |
| CN-110267649-A | Immunomodulatory compounds | 兰肯瑙医学研究所 | 2019-09-20 | — | — | CN | disclosed |
| CN-109970639-A | The method of piperaquine intermediate is synthesized in a kind of continuous current micro-reactor | 重庆康乐制药有限公司 | 2019-07-05 | — | — | CN | disclosed |
| CN-106098722-B | A kind of image sensing device and preparation method thereof and application method | 清华大学 | 2019-07-02 | — | — | CN | disclosed |
| CN-109928997-A | Electroluminescent organic material and device | 环球展览公司 | 2019-06-25 | — | — | CN | disclosed |
| CN-107847398-B | Control the pharmaceutical dosage form of release | 南京三迭纪医药科技有限公司 | 2019-05-07 | — | — | CN | disclosed |
| CN-109476626-A | Compound, material for organic electroluminescent element, and electronic device | 出光兴产株式会社 | 2019-03-15 | — | — | CN | disclosed |
| CN-109384780-A | Tetrahydro-proto-berberine compounds, preparation method, purposes and pharmaceutical composition | 中国科学院上海药物研究所 | 2019-02-26 | — | — | CN | disclosed |
| CN-109180441-A | A kind of synthetic method of triethyl orthoformate | 江苏远大仙乐药业有限公司 | 2019-01-11 | — | — | CN | disclosed |
| CN-109152763-A | Artesunate-containing composition | 赵鸣 | 2019-01-04 | — | — | CN | disclosed |
| CN-109010916-A | Containing the mouldable preparation of aerobic sterol in acellular tissue matrices | 华沙整形外科股份有限公司 | 2018-12-18 | — | — | CN | disclosed |
| CN-108883119-A | The method of separation and detection oxidation sterol | 华沙整形外科股份有限公司 | 2018-11-23 | — | — | CN | disclosed |
| CN-108721242-A | Pharmaceutical formulation and its use | 南京三迭纪医药科技有限公司 | 2018-11-02 | — | — | CN | disclosed |
| CN-108699005-A | 3- (carboxy ethyl) -8- amino -2- oxo -1,3- aza-spiros-[4.5]Decane derivative | 格吕伦塔尔有限公司 | 2018-10-23 | — | — | CN | disclosed |
| CN-108653221-A | Pharmaceutical formulation and its use | 南京三迭纪医药科技有限公司 | 2018-10-16 | — | — | CN | disclosed |
| CN-108602777-A | 3- ((miscellaneous -) aryl)-alkyl -8- amino -2- oxos -1,3- aza-spiro-[4.5]-decane derivative | 格吕伦塔尔有限公司 | 2018-09-28 | — | — | CN | disclosed |
| CN-103842818-B | Rapid fluorescent labeling of glycans and other biomolecules with enhanced MS signal | 沃特世科技公司 | 2018-09-21 | — | — | CN | disclosed |
| CN-103728805-B | Display particle dispersion, display medium and display device | 电子墨水公司 | 2018-09-11 | — | — | CN | disclosed |
| CN-108495853-A | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CRYPTOSPORIDIOSIS | 诺华股份有限公司 | 2018-09-04 | — | — | CN | disclosed |
| CN-108456250-A | Target antibody and its application of IL-13RA2 | 科济生物医药（上海）有限公司 | 2018-08-28 | — | — | CN | disclosed |
| CN-108203367-A | A kind of synthetic method of triethyl orthoformate | 青岛祥智电子技术有限公司 | 2018-06-26 | — | — | CN | disclosed |
| CN-105790732-B | A kind of multiple signals stacking apparatus | 清华大学 | 2018-05-29 | — | — | CN | disclosed |
| WO-2018087775-A1 | PROCESSES FOR THE PREPARATION OF 7-{4-[4-(1-BENZOTHIOPHEN-4-YL)PIPERAZIN-1-YL]BUTOXY}QUINOLIN-2(1H)-ONE | MSN LABORATORIES PRIVATE LIMITED, R&D CENTER (IN) | 2018-05-17 | — | — | WO | disclosed |
| CN-107922339-A | Platelet storage methods and compositions for use in said methods | 儿童医院医学中心 | 2018-04-17 | — | — | CN | disclosed |
| CN-107921113-A | Immunomodulatory compositions and methods of use thereof | 巴比塔·阿格拉沃尔 | 2018-04-17 | — | — | CN | disclosed |
| CN-103387583-B | Diaryl simultaneously [a, g] quinolizine class compound, its preparation method, pharmaceutical composition and its application | 中国科学院上海药物研究所 | 2018-04-13 | — | — | CN | disclosed |
| CN-107867983-A | A kind of synthetic method of triethyl orthoformate | 青岛九洲千和机械有限公司 | 2018-04-03 | — | — | CN | disclosed |
| CN-107847398-A | The pharmaceutical dosage form of control release | 南京三迭纪医药科技有限公司 | 2018-03-27 | — | — | CN | disclosed |
| CN-107778287-A | A kind of compound as tyrosine protein kinase inhibitor | 南昌弘益药业有限公司 | 2018-03-09 | — | — | CN | disclosed |
| CN-206934352-U | Pharmaceutical formulation | 南京三迭纪医药科技有限公司 | 2018-01-30 | — | — | CN | disclosed |
| CN-104025265-B | Polishing composition | 福吉米株式会社 | 2018-01-12 | — | — | CN | disclosed |
| CN-107496574-A | A kind of Chinese medicine preparation for treating cough and preparation method thereof | 合肥川迪医药技术有限公司 | 2017-12-22 | — | — | CN | disclosed |
| CN-107405870-A | Layered product, temporary bond composition and temporary bond film | 富士胶片株式会社 | 2017-11-28 | — | — | CN | disclosed |
| CN-107383058-A | Preparation of marbofloxacin | 海门慧聚药业有限公司 | 2017-11-24 | — | — | CN | disclosed |
| CN-105646277-B | Quinone derivative and electrophotographic photoreceptor | 京瓷办公信息系统株式会社 | 2017-10-24 | — | — | CN | disclosed |
| CN-105339370-B | Compound and and its pharmaceutical composition for treating diseases associated with inflammation | 加拉帕戈斯股份有限公司 | 2017-09-15 | — | — | CN | disclosed |
| CN-107108485-A | KCNQ 2-5 channel activator | 小野药品工业株式会社 | 2017-08-29 | — | — | CN | disclosed |
| CN-107111253-A | Organic processing liquid and pattern forming method | 富士胶片株式会社 | 2017-08-29 | — | — | CN | disclosed |
| CN-107001360-A | 4H-pyrido [1,2-a ] pyrimidin-4-one compounds | 普拉纳生物技术有限公司 | 2017-08-01 | — | — | CN | disclosed |
| CN-105198884-B | Pentacyclic indole quinolizine that the G1/G0 phases block, its synthesis, antitumor activity and application | 首都医科大学 | 2017-08-01 | — | — | CN | disclosed |
| CN-104610774-B | Second nonlinear optic compound and the nonlinear optical element containing it | 独立行政法人情报通信研究机构 | 2017-07-18 | — | — | CN | disclosed |
| CN-106699524-A | Synthetic method of triethyl orthoformate | 青岛森美克化工技术有限公司 | 2017-05-24 | — | — | CN | disclosed |
| CN-104022135-B | Optical coupler and preparation method for same | 清华大学 | 2017-05-03 | — | — | CN | disclosed |
| CN-206120770-U | Medicine formulation | 南京三迭纪医药科技有限公司 | 2017-04-26 | — | — | CN | disclosed |
| CN-206120771-U | Medicine formulation | 南京三迭纪医药科技有限公司 | 2017-04-26 | — | — | CN | disclosed |
| CN-105164124-B | Compounds and compositions for treating parasitic diseases | 诺华股份有限公司 | 2017-03-15 | — | — | CN | disclosed |
| CN-106414410-A | Molecules having certain pesticidal utility, and intermediates, compositions, and methods related thereto | 美国陶氏益农公司 | 2017-02-15 | — | — | CN | disclosed |
| EP-2718268-B1 | NOVEL PROCESS FOR THE SYNTHESIS OF 7-CHLORO-4-(PIPERAZIN-1-YL)-QUINOLINE | SIGMA TAU IND FARMACEUTI (IT) | 2016-12-28 | — | — | EP | disclosed |
| CN-103289432-B | Electrophoresis particle, electrophoretic particle dispersion liquid, display medium and display device | 富士施乐株式会社 | 2016-12-28 | — | — | CN | disclosed |
| CN-103664974-B | Aryl [a] indole [2,3-g] quinolizine compounds, its preparation method, pharmaceutical composition and application thereof | 中国科学院上海药物研究所 | 2016-12-21 | — | — | CN | disclosed |
| CN-104557973-B | 3,3 '-methylene of a kind of chirality piperazine quinoline ring-bis-fluoro quinolone derivatives and its preparation method and application | 河南大学 | 2016-11-23 | — | — | CN | disclosed |
| CN-104557973-B | 3,3 '-methylene of a kind of chirality piperazine quinoline ring-bis-fluoro quinolone derivatives and its preparation method and application | 河南大学 | 2016-11-23 | — | — | CN | disclosed |
| CN-106133601-A | Sensitized ray or the manufacture method of radiation-sensitive resin composition, sensitized ray or radiation-sensitive resin composition, sensitized ray or radioactivity-sensitive film, possess sensitized ray or the blank mask of radioactivity-sensitive film, photomask, pattern formation method, the manufacture method of electronic device and electronic device | 富士胶片株式会社 | 2016-11-16 | — | — | CN | disclosed |
| CN-106098722-A | A kind of image sensing device and preparation method thereof and using method | 清华大学 | 2016-11-09 | — | — | CN | disclosed |
| CN-106045936-A | COMPOSITIONS, SYNTHESIS, AND METHODS OF UTILIZING ARYLPIPERAZINE DERIVATIVES | 雷维瓦药品公司 | 2016-10-26 | — | — | CN | disclosed |
| CN-106008500-A | Corynantheidine compounds and preparation method thereof | 复旦大学 | 2016-10-12 | — | — | CN | disclosed |
| CN-104053675-B | Low anticoagulant heparin | 迪乐方特有限责任公司 | 2016-10-12 | — | — | CN | disclosed |
| CN-102796096-B | Hexahydro dibenzo [a, g] quinolizine compounds, its preparation method, pharmaceutical composition and application thereof | 中国科学院上海药物研究所 | 2016-09-14 | — | — | CN | disclosed |
| CN-105934458-A | Polymerizable composition for optical material, optical material obtained from the composition, and plastic lens | 三井化学株式会社 | 2016-09-07 | — | — | CN | disclosed |
| CN-105790732-A | Multipath signal superposition device | 清华大学 | 2016-07-20 | — | — | CN | disclosed |
| CN-103579282-B | Integrated optocoupler of a kind of multichannel and preparation method thereof | TSINGHUA UNIVERSITY (CN) | 2016-04-06 | — | — | CN | disclosed |
| CN-103483165-B | Prepare the green cleaning procedure of ortho-formiate | HEBEI CHENGXIN CO., LTD. (CN) | 2016-02-24 | — | — | CN | disclosed |
| CN-105189506-A | Compounds and compositions for the treatment of parasitic diseases | NOVARTIS AG | 2015-12-23 | — | — | CN | disclosed |
| CN-105164124-A | Compounds and compositions for treating parasitic diseases | NOVARTIS AG | 2015-12-16 | — | — | CN | disclosed |
| US-9206133-B2 | Process for the synthesis of 7-chloro-4-(piperazin-1-yl)-quinoline | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2015-12-08 | — | — | US | disclosed |
| CN-104755083-A | Urea and amide derivatives of aminoalkylpiperazines and use thereof | SOUTHERN RES INST | 2015-07-01 | — | — | CN | disclosed |
| CN-103664552-B | Synthesis method for triethyl orthoformate | ZHAO YIFAN | 2015-06-10 | — | — | CN | disclosed |
| CN-104684396-A | Tricyclic tetrahydroquinoline antibacterial agents | ZOETIS LLC | 2015-06-03 | — | — | CN | disclosed |
| CN-102898428-B | Microwave synthesis method of spirocyclopiperazinium compound | UNIV CHANGZHOU | 2015-04-22 | — | — | CN | disclosed |
| US-8951988-B2 | Azidothymidine quinoline conjugated compound, preparation method therefor and application thereof in anti-hepatoma therapy | HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2015-02-10 | — | — | US | disclosed |
| US-20140256670-A1 | AZIDOTHYMIDINE QUINOLINE CONJUGATED COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF IN ANTI-HEPATOMA THERAPY | HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2014-09-11 | — | — | US | disclosed |
| CN-104022135-A | Optical coupler and preparation method for same | UNIV TSINGHUA | 2014-09-03 | — | — | CN | disclosed |
| US-20140200346-A1 | Novel Process for the Synthesis of 7-Chloro-4-(piperazin-1-yl)-quinoline | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2014-07-17 | — | — | US | disclosed |
| EP-2718268-A2 | NOVEL PROCESS FOR THE SYNTHESIS OF 7-CHLORO-4-(PIPERAZIN-1-YL)-QUINOLINE | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. (IT) | 2014-04-16 | — | — | EP | disclosed |
| CN-103664552-A | Synthesis method for triethyl orthoformate | ZHAO YIFAN | 2014-03-26 | — | — | CN | disclosed |
| CN-103596927-A | Novel process for the synthesis of 7-chloro-4-(piperazin-1-yl)-quinoline | SIGMA TAU IND FARMACEUTI | 2014-02-19 | — | — | CN | disclosed |
| CN-103579282-A | Multi-channel integrated optical couplers and method for manufacturing same | UNIV TSINGHUA | 2014-02-12 | — | — | CN | disclosed |
| CN-103483165-A | Green process for preparing orthoformate | Hebei chengxin co ltd | 2014-01-01 | — | — | CN | disclosed |
| CN-103041838-A | Catalyst for preparing 2, 6-dichlorobenzonitrile from 2, 6-dichlorotoluene by means of ammoxidation | WUHAN JINFU TECHNOLOGY CO LTD | 2013-04-17 | — | — | CN | disclosed |
| CN-101272777-B | Stable dosage forms of spiro and dispiro 1,2, 4-trioxolane antimalarials | RANBAXY LAB LTD | 2013-01-30 | — | — | CN | disclosed |
| CN-102898428-A | Microwave synthesis method of spirocyclopiperazinium compound | UNIV CHANGZHOU | 2013-01-30 | — | — | CN | disclosed |
| WO-2012168213-A2 | NOVEL PROCESS FOR THE SYNTHESIS OF 7-CHLORO-4-(PIPERAZIN-1-YL)-QUINOLINE | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2012-12-13 | — | — | WO | disclosed |
| CN-102822746-A | Pattern forming method and resist composition | FUJIFILM CORP | 2012-12-12 | — | — | CN | disclosed |
| CN-102812400-A | Actinic ray-sensitive or radiation-sensitive resin composition and pattern forming method using same | FUJIFILM CORP | 2012-12-05 | — | — | CN | disclosed |
| CN-102812006-A | New anti-malarial agents | MEDICINES FOR MALARIA VENTURE MMV | 2012-12-05 | — | — | CN | disclosed |
| CN-102558048-A | Polycrystal substance of piperaquine phosphate and preparation method thereof | ZHUHAI RUNDU PHARMACEUTICAL CO LTD | 2012-07-11 | — | — | CN | disclosed |
| CN-102395565-A | Compounds having antiparasitic or anti-infectious activity | UNIV OREGON HEALTH & SCIENCE (US) | 2012-03-28 | — | — | CN | disclosed |
| CN-202145468-U | Flexible organic electroluminescent device | BOE TECHNOLOGY GROUP CO LTD | 2012-02-15 | — | — | CN | disclosed |
| US-8071768-B2 | Alkylquinoline and alkylquinazoline kinase modulators | JANSSEN PHARMACEUTICA, N.V. (BE) | 2011-12-06 | — | — | US | disclosed |
| CN-101575327-B | Antimalarial active isocumarans compound and composition, preparation method and application thereof | GUANGZHOU INST BIOMED & HEALTH | 2011-09-14 | — | — | CN | disclosed |
| CN-101440063-B | Preparation of piperaquini phosphatis | CHONGQING KANGLE PHARMACEUTICAL CO LTD | 2011-07-13 | — | — | CN | disclosed |
| CN-102015607-A | 1, 4-naphthoquinone derivatives and therapeutic uses thereof | CENTRE NAT RECH SCIENT | 2011-04-13 | — | — | CN | disclosed |
| CN-102015711-A | Spiro-indole derivatives for the treatment of parasitic diseases | NOVARTIS AG | 2011-04-13 | — | — | CN | disclosed |
| US-7825244-B2 | Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis | JANSSEN PHARMACEUTICA NV (BE) | 2010-11-02 | — | — | US | disclosed |
| CN-101842377-A | Two spiral shells 1,2,4-trioxa pentamethylene antimalarial drug | MEDICINES MALARIA VENTURE MMV | 2010-09-22 | — | — | CN | disclosed |
| CN-101240344-B | Plasmodium falciparum medicament resistance related gene polymorphism detecting chip and application thereof | NAT INST FOR PARASITIC DISEASES CHINESE CT FOR DISEASE CONTROL AND PREVENTION | 2010-09-08 | — | — | CN | disclosed |
| CN-101783358-A | Organic optical coupler component | UNIV TSINGHUA | 2010-07-21 | — | — | CN | disclosed |
| CN-1689186-B | Proton conducting membrane and application thereof | BASF FUEL CELL GMBH | 2010-06-16 | — | — | CN | disclosed |
| CN-201373373-Y | Brick lamp | KUNSHAN VISIONOX DISPLAY TECH | 2009-12-30 | — | — | CN | disclosed |
| CN-101575327-A | Antimalarial active isocumarans compound and composition, preparation method and application thereof | CHINESE ACADEMY OF SCIENCES GU (CN) | 2009-11-11 | — | — | CN | disclosed |
| CN-101466680-A | Process for synthesizing piperazine-piperidine compounds | WYETH CORP (US) | 2009-06-24 | — | — | CN | disclosed |
| CN-101442043-A | Organic light coupling device | UNIV TSINGHUA (CN) | 2009-05-27 | — | — | CN | disclosed |
| CN-101440063-A | Preparation of piperaquini phosphatis | CHONGQING KANGLE PHARMACEUTICA (CN) | 2009-05-27 | — | — | CN | disclosed |
| WO-2008067390-A9 | METABOLITES OF 5-FLUORO-8-{4-[4-(6-METHOXYQUINOLIN-8-YL)PIPERAZIN-1-YL]PIPERIDIN-1-YL} QUINOLINE AND METHODS OF PREPARATION AND USES THEREOF | WYETH CORP (US) | 2009-05-22 | — | — | WO | disclosed |
| CN-100484353-C | Organic electroluminescent part | TSINGHUA UNIVERSITY KUNSHAN VI (CN) | 2009-04-29 | — | — | CN | disclosed |
| CN-101392101-A | Processed pigment, pigment-dispersed composition, colored photosensitive composition, color filter, liquid crystal display element, and solid image pickup element | FUJIFILM CORP (JP) | 2009-03-25 | — | — | CN | disclosed |
| CN-101394696-A | Organic EL device | UNIV TSINGHUA (CN) | 2009-03-25 | — | — | CN | disclosed |
| CN-100448051-C | Organic electroluminescence device | UNIV TSINGHUA (CN) | 2008-12-31 | — | — | CN | disclosed |
| CN-101300249-A | Aminoquinoline and aminoquinazoline kinase modulators | JANSSEN PHARMACEUTICA NV (BE) | 2008-11-05 | — | — | CN | disclosed |
| CN-101293871-A | 7-chlorine-4-[4'-(7''-chloroquine-4''-base)diethylenediamine-1'-base]quinoline and uses thereof | INST OF TROPICAL MEDICINE OF G (CN) | 2008-10-29 | — | — | CN | disclosed |
| US-20080262228-A1 | Metabolites of 5-fluoro-8- quinoline and methods of preparation and uses thereof | WYETH (US) | 2008-10-23 | — | — | US | disclosed |
| CN-101289423-A | 7-chlorine -4-(1- piperazinyl)chinoline and applications thereof in preparation of anti-malaria medicaments | INST OF TROPICAL MEDICINE OF G (CN) | 2008-10-22 | — | — | CN | disclosed |
| CN-101272777-A | Stable dosage forms of spiro and dispiro 1,2, 4-trioxolane antimalarials | RANBAXY LAB LTD (IN) | 2008-09-24 | — | — | CN | disclosed |
| CN-101243065-A | Intermediates for the synthesis of alkylquinoline and alkylquinazoline kinase modulators and related synthetic methods | JANSSEN PHARMACEUTICA NV (BE) | 2008-08-13 | — | — | CN | disclosed |
| CN-101240344-A | Plasmodium falciparum medicament resistance related gene polymorphism detecting chip and application thereof | NAT INST FOR PARASITIC DISEASE (CN) | 2008-08-13 | — | — | CN | disclosed |
| CN-101237731-A | An organic EL part | UNIV TSINGHUA (CN) | 2008-08-06 | — | — | CN | disclosed |
| WO-2008067390-A2 | METABOLITES OF 5-FLUORO-8-{4-[4-(6-METHOXYQUINOLIN-8-YL)PIPERAZIN-1-YL]PIPERIDIN-1-YL} QUINOLINE AND METHODS OF PREPARATION AND USES THEREOF | WYETH (US) | 2008-06-05 | — | — | WO | disclosed |
| EP-1893598-A1 | ALKYLQUINOLINE AND ALKYLQUINAZOLINE KINASE MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-03-05 | — | — | EP | disclosed |
| EP-1891040-A1 | INTERMEDIATES USEFUL IN THE SYNTHESIS OF ALKYLQUINOLINE AND ALKYLQUINAZOLINE KINASE MODULATORS AND RELATED METHODS OF SYNTHESIS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-02-27 | — | — | EP | disclosed |
| CN-100340024-C | Membrane electrode unit comprising a polyimide layer | PEMEAS GMBH (DE) | 2007-09-26 | — | — | CN | disclosed |
| CN-1320001-C | Novel polyvinyl esters | CELANESE VENTURES GMBH (DE) | 2007-06-06 | — | — | CN | disclosed |
| CN-1315836-C | 2- (quinolonyl) -fused heterocycles as androgen receptor modulators | ORTHO MCNEIL PHARM INC (US) | 2007-05-16 | — | — | CN | disclosed |
| CN-1297588-C | Polymer film based on polyazoles, and use thereof | PEMEAS GMBH (DE) | 2007-01-31 | — | — | CN | disclosed |
| US-20070021436-A1 | INTERMEDIATES USEFUL IN THE SYNTHESIS OF ALKYLQUINOLINE AND ALKYLQUINAZOLINE KINASE MODULATORS, AND RELATED METHODS OF SYNTHESIS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-01-25 | — | — | US | disclosed |
| CN-1897311-A | Organic optical coupler device | UNIV TSINGHUA (CN) | 2007-01-17 | — | — | CN | disclosed |
| US-20070004763-A1 | AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-01-04 | — | — | US | disclosed |
| WO-2006135646-A1 | INTERMEDIATES USEFUL IN THE SYNTHESIS OF ALKYLQUINOLINE AND ALKYLQUINAZOLINE KINASE MODULATORS AND RELATED METHODS OF SYNTHESIS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-12-21 | — | — | WO | disclosed |
| WO-2006135721-A1 | ALKYLQUINOLINE AND ALKYLQUINAZOLINE KINASE MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-12-21 | — | — | WO | disclosed |
| US-20060281772-A1 | ALKYLQUINOLINE AND ALKYLQUINAZOLINE KINASE MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-12-14 | — | — | US | disclosed |
| CN-1826116-A | Piperidine derivatives as melanocortin-4 receptor agonists | MERCK & CO INC (US) | 2006-08-30 | — | — | CN | disclosed |
| CN-1689186-A | Proton conducting membrane and application thereof | PEMEAS GMBH (DE) | 2005-10-26 | — | — | CN | disclosed |
| CN-1678645-A | Novel polyvinyl esters | CELANESE VENTURES GMBH (DE) | 2005-10-05 | — | — | CN | disclosed |
| CN-1678663-A | Polypyrrole-based polymer membranes and their use | PEMEAS GMBH (DE) | 2005-10-05 | — | — | CN | disclosed |
| CN-1675788-A | Membrane electrode assembly comprising polyimide layer | PEMEAS GMBH (DE) | 2005-09-28 | — | — | CN | disclosed |
| CN-1662540-A | 2- (quinolonyl) -fused heterocycles as androgen receptor modulators | ORTHO MCNEIL PHARM INC (US) | 2005-08-31 | — | — | CN | disclosed |
| CN-1205185-C | Nitrogen-containing cyclic compound and pharmaceutical composition containing the same | EISAI CO LTD (JP) | 2005-06-08 | — | — | CN | disclosed |
| US-20050107372-A1 | 2-(Quinolonyl)-fused heterocycles as androgen receptor modulators | LANTER JAMES C (US) | 2005-05-19 | — | — | US | disclosed |
| CN-1191254-C | Fused pyrrole compounds, pharmaceutical composition containing the same, and the use thereof | MARCKLE GMBH (DE) | 2005-03-02 | — | — | CN | disclosed |
| US-6858621-B2 | 2-(quinolonyl)-fused heterocycles as androgen receptor modulators | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2005-02-22 | — | — | US | disclosed |
| EP-1501835-A2 | 2-(QUINOLONYL)-FUSED HETEROCYCLES AS ANDROGEN RECEPTOR MODULATORS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2005-02-02 | — | — | EP | disclosed |
| CN-1564641-A | Organic electroluminescence device | UNIV TSINGHUA (CN) | 2005-01-12 | — | — | CN | disclosed |
| US-20040014743-A1 | 2-(Quinolonyl)-fused heterocycles as androgen receptor modulators | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-01-22 | — | — | US | disclosed |
| WO-2003090672-A2 | 2-(QUINOLONYL)-FUSED HETEROCYCLES AS ANDROGEN RECEPTOR MODULATORS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-11-06 | — | — | WO | disclosed |
| CN-1418217-A | Fused pyrrole compounds, pharmaceutical composition containing the same, and the use thereof | MARCKLE GMBH (DE) | 2003-05-14 | — | — | CN | disclosed |
| CN-1395562-A | Nitrogenous cyclic compounds and pharmaceutical compositions containing the same | EISAI CO LTD (JP) | 2003-02-05 | — | — | CN | disclosed |
| CN-1315858-A | Novel remedies for allergic diseases | FUJI YAKUHIN KOGYO KK (JP) | 2001-10-03 | — | — | CN | disclosed |
| CN-1052232-C | 3N-alkyl-3,4-dihydro-2H-4-substituted heteroaromatic azyl-7,8,9,10(7,10)-naphthane-(2,1-e)-(1,3) | MICROORGANISM EPIDEMIC INST MI (CN) | 2000-05-10 | — | — | CN | disclosed |
| CN-1034331-C | Amines and their use | MITSUI PHARMACEUTICALS LTD (JP) | 1997-03-26 | — | — | CN | disclosed |
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| CN-1054718-A | Collyrium | CHINOIN GYOGYSZER ES VEGYESZET (HU) | 1991-09-25 | — | — | CN | disclosed |
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Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040014743-A1 | 2-(Quinolonyl)-fused heterocycles as androgen receptor modulators | AR, NR5A1, ESRRA | ALDH1A1 708/4885NPC1 1618/4885POLB 2475/4885 |
| US-20070021436-A1 | INTERMEDIATES USEFUL IN THE SYNTHESIS OF ALKYLQUINOLINE AND ALKYLQUINAZOLINE KINASE MODULATORS, AND RELATED METHODS OF SYNTHESIS | FLT3, ABL1, KIT | ALDH1A1 2867/4885NPC1 4264/4885POLB 3499/4885 |
| US-20230203063-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | TYMS, TYMP, DHFR | ALDH1A1 547/4885NPC1 3090/4885POLB 329/4885 |
| US-20220119409-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | DHFR, TYMS, TYMP | ALDH1A1 564/4885NPC1 3126/4885POLB 432/4885 |
| US-20140256670-A1 | AZIDOTHYMIDINE QUINOLINE CONJUGATED COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF IN ANTI-HEPATOMA THERAPY | GOT1, WEE1, HCCS | ALDH1A1 687/4885NPC1 1601/4885POLB 1703/4885 |
| US-20050107372-A1 | 2-(Quinolonyl)-fused heterocycles as androgen receptor modulators | AR, NR5A1, CYP19A1 | ALDH1A1 886/4885NPC1 2200/4885POLB 2417/4885 |
| US-20060281772-A1 | ALKYLQUINOLINE AND ALKYLQUINAZOLINE KINASE MODULATORS | FLT3, KIT, NTRK2 | ALDH1A1 2024/4885NPC1 2872/4885POLB 2073/4885 |
| US-20070004763-A1 | AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS | FLT3, BMX, ABL1 | ALDH1A1 3033/4885NPC1 3833/4885POLB 1726/4885 |
| US-11279696-B2 | Processes for the preparation of 7-{4-[4-(1-benzothiophen-4-yl) piperazin-1-yl]butoxy}quinolin-2(1H)-one | CYP1B1, CYP4B1, CYP1A1 | ALDH1A1 244/4885NPC1 1265/4885POLB 870/4885 |
| US-20140200346-A1 | Novel Process for the Synthesis of 7-Chloro-4-(piperazin-1-yl)-quinoline | CYP3A7, UGT1A7, RAB7A | ALDH1A1 539/4885NPC1 578/4885POLB 236/4885 |
| US-20080262228-A1 | Metabolites of 5-fluoro-8- quinoline and methods of preparation and uses thereof | UGT1A8, CYP2C8, NQO1 | ALDH1A1 416/4885NPC1 298/4885POLB 3398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.