Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.66 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | BCHE | P06276 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | KDM1A | O60341 | 1/20 | 0.53 |
| ▸ | CA4 | P22748 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7346729 | 0.91 | ALDH1A1 (0.61) | LTA4HHTTNPC1ALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7034100 | 0.89 | ALDH1A1 (0.59) | LTA4HHTTNPC1ALDH1A1MEN1 | |
| SCHEMBL1279045 | 0.88 | HTT (0.73) | LTA4HHTTNPC1ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL9737805 | 0.83 | MAOB (0.55) | LTA4HHTTNPC1ALDH1A1KDM4E | |
| SCHEMBL28872015 | 0.83 | ALDH1A1 (0.53) | LTA4HHTTNPC1ALDH1A1MEN1 | |
| SCHEMBL8349970 | 0.83 | ACHE (0.62) | NPC1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL8415551 | 0.82 | HTT (0.58) | HTTALDH1A1SMN1; SMN2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL7335796 | 0.82 | ALDH1A1 (0.52) | HTTNPC1ALDH1A1MEN1KMT2A | |
| SCHEMBL13325954 | 0.81 | APP (0.67) | LTA4HHTTSMN1; SMN2 | |
| SCHEMBL14137298 | 0.81 | ALDH1A1 (0.55) | LTA4HHTTNPC1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1259489-A1 | ARYL FUSED AZAPOLYCYCLIC COMPOUNDS | Pfizer Products Inc. (US) | 2002-11-27 | — | — | EP | disclosed |
| WO-2001062736-A1 | ARYL FUSED AZAPOLYCYCLIC COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2001-08-30 | — | — | WO | disclosed |