Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP4 | P15090 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.34 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7484157 | 0.81 | CXCR2 (0.46) | FABP4SMN1; SMN2KMT2AHTTNPC1 | |
| SCHEMBL5594997 | 0.74 | SMN1; SMN2 (0.40) | SMN1; SMN2TAS2R14L3MBTL1PDK1PDK2 | |
| SCHEMBL5594826 | 0.70 | CXCR2 (0.57) | KMT2AHTTNPC1RAB9AGAA | |
| SCHEMBL3710835 | 0.70 | HTT (0.56) | SMN1; SMN2L3MBTL1PDK1PDK2PDK3 | |
| SCHEMBL6824698 | 0.66 | HNF4A (0.35) | FABP4ALDH1A1LMNAHDAC8HDAC6 | |
| SCHEMBL7490879 | 0.65 | ALDH1A1 (0.52) | FABP4ALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL6823287 | 0.65 | CXCR2 (0.60) | SMN1; SMN2KMT2AHTTNPC1RAB9A | |
| SCHEMBL14832613 | 0.64 | HNF4A (0.48) | FABP4PDK2ALDH1A1LMNAHDAC8 | |
| SCHEMBL6824149 | 0.64 | CXCR2 (0.48) | SMN1; SMN2L3MBTL1KMT2AHTTNPC1 | |
| SCHEMBL27535605 | 0.63 | SMN1; SMN2 (0.39) | SMN1; SMN2TAS2R14L3MBTL1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0896531-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2002-10-30 | — | — | EP | disclosed |
| EP-0896531-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-02-17 | — | — | EP | disclosed |
| WO-1997029743-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-08-21 | — | — | WO | disclosed |