Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7431721 | 0.85 | ADORA2A (0.56) | THRBMAPTADORA2ATP53ADORA1 | |
| SCHEMBL7708996 | 0.84 | ADORA3 (0.51) | THRBMAPTADORA2AADORA1ADORA3 | |
| SCHEMBL6872375 | 0.82 | ADORA2A (0.60) | THRBMAPTADORA2ASMN1; SMN2TP53 | |
| SCHEMBL7709116 | 0.81 | ADORA2A (0.48) | THRBMAPTADORA2ASMN1; SMN2TP53 | |
| SCHEMBL7711822 | 0.80 | PDE2A (0.42) | THRBMAPTTP53 | |
| SCHEMBL7703042 | 0.79 | ADORA2A (0.52) | THRBMAPTADORA2A | |
| SCHEMBL7705858 | 0.79 | MAPT (0.46) | THRBMAPTTP53 | |
| SCHEMBL7703121 | 0.78 | ADORA2A (0.62) | THRBMAPTADORA2ASMN1; SMN2TP53 | |
| SCHEMBL7708919 | 0.77 | ADORA2A (0.56) | MAPTADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL7705841 | 0.76 | ADORA2A (0.56) | ADORA2AADORA1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214322-A2 | AMINO-TRIAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-19 | — | — | EP | claimed |
| US-6355653-B1 | DRUG AND CARRIER FOR ANTIALLERGENS, BRAIN DISORDERS AND NEUROTRANSMITTERS | HOFFMANN-LA ROCHE INC. | 2002-03-12 | — | — | US | claimed |
| WO-2001017999-A2 | AMINO-TRIAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-03-15 | — | — | WO | claimed |
| EP-1214322-A2 | AMINO-TRIAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-19 | — | — | EP | disclosed |
| US-6355653-B1 | DRUG AND CARRIER FOR ANTIALLERGENS, BRAIN DISORDERS AND NEUROTRANSMITTERS | HOFFMANN-LA ROCHE INC. | 2002-03-12 | — | — | US | disclosed |
| WO-2001017999-A2 | AMINO-TRIAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-03-15 | — | — | WO | disclosed |