Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 3/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7485077 | 0.86 | HRH3 (0.41) | RAB9ANPC1SIGMAR1TMEM97HPGD | |
| SCHEMBL7481478 | 0.83 | TMEM97 (0.36) | RAB9ANPC1SIGMAR1TMEM97HPGD | |
| SCHEMBL8195562 | 0.83 | ESR1 (0.39) | RAB9ANPC1SIGMAR1TMEM97SMN1; SMN2 | |
| SCHEMBL8195897 | 0.82 | DHODH (0.43) | RAB9ANPC1DHODHCNR1CNR2 | |
| SCHEMBL7487453 | 0.82 | DHODH (0.43) | RAB9ANPC1DHODHCNR1CNR2 | |
| SCHEMBL7538218 | 0.80 | SIGMAR1 (0.47) | SIGMAR1TMEM97MEN1KMT2ADRD2 | |
| SCHEMBL7481181 | 0.79 | LMNA (0.48) | CNR2MEN1LMNAKMT2A | |
| SCHEMBL7485060 | 0.79 | SMN1; SMN2 (0.40) | RAB9ADHODHHPGDHTTMEN1 | |
| SCHEMBL8196776 | 0.76 | KDM4E (0.50) | RAB9ANPC1HPGDHTTMEN1 | |
| SCHEMBL8183672 | 0.75 | HPGD (0.55) | RAB9ANPC1SIGMAR1HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1204644-A1 | SYNTHESIS OF SUBSTITUTED AMIDINES | ELI LILLY AND COMPANY (US) | 2002-05-15 | — | — | EP | disclosed |
| WO-2000078725-A1 | SYNTHESIS OF SUBSTITUTED AMIDINES | ELI LILLY AND COMPANY (US) | 2000-12-28 | — | — | WO | disclosed |
| WO-2000078724-A2 | IMIDAZOLINDERIVATIVES THEIR PREPARATION AND THEIR PHARMACEUTICAL USE | ELI LILLY AND COMPANY (US) | 2000-12-28 | — | — | WO | disclosed |