SCHEMBL7485385

SCHEMBL7485385

NCCOc1cc(Cl)cc([N+](=O)[O-])c1N

nearest known ligand 0.42

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PDE7A Q13946 2/20 0.40
S1PR4 O95977 6/20 0.40
NPC1 O15118 1/20 0.39
RECQL P46063 1/20 0.39
RAB9A P51151 1/20 0.39
PRSS1 P07477 4/20 0.37
ALDH1A1 P00352 2/20 0.36
CYP3A4 P08684 1/20 0.36
MAPT P10636 1/20 0.35
PDE7B Q9NP56 1/20 0.35
MEN1 O00255 1/20 0.35
TTR P02766 1/20 0.35
ALB P02768 1/20 0.35
THRB P10828 1/20 0.35
KMT2A Q03164 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
KDM4E B2RXH2 1/20 0.34
TSHR P16473 1/20 0.34
MAPK1 P28482 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7334439 0.88 PDE7A (0.40) PDE7AS1PR4NPC1RECQLRAB9A
SCHEMBL4018068 0.78 KDM4E (0.47) PDE7ANPC1RAB9AALDH1A1CYP3A4
SCHEMBL28521933 0.77 PIN1 (0.49) NPC1RAB9ACYP3A4MAPTMEN1
SCHEMBL8118187 0.77 KDM4E (0.49) CYP3A4MAPTMEN1THRBKMT2A
SCHEMBL7336105 0.76 KDM4E (0.60) CYP3A4MEN1KMT2AKDM4E
SCHEMBL2912091 0.76 ALDH1A1 (0.50) PDE7AALDH1A1CYP3A4MAPTPDE7B
SCHEMBL7335224 0.73 POLB (0.43) PDE7AS1PR4PRSS1ALDH1A1MAPT
SCHEMBL7334343 0.73 DRD2 (0.45) PDE7AALDH1A1MAPTKDM4E
SCHEMBL29960239 0.72 TDP1 (0.51) PDE7ANPC1RECQLRAB9APRSS1
SCHEMBL3011561 0.72 ALDH1A1 (0.43) PDE7AALDH1A1CYP3A4MAPTPDE7B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1068184-B1 N-ARYLOXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF DEPRESSION WYETH CORP (US) 2002-09-04 EP disclosed
EP-1068184-A1 N-ARYLOXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF DEPRESSION AMERICAN HOME PRODUCTS CORPORATION (US) 2001-01-17 EP disclosed
US-6110956-A ANTIDEPRESSANTS TREATING DISORDERS OF THE SEROTONIN-AFFECTED NEUROLOGICAL SYSTEMS AMERICAN HOME PRODUCTS CORP. (US) 2000-08-29 US disclosed
WO-1999051576-A1 N-ARYLOXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF DEPRESSION AMERICAN HOME PRODUCTS CORPORATION (US) 1999-10-14 WO disclosed