SCHEMBL7485442

SCHEMBL7485442

Oc1cccc2c1CCC(NCc1nc(-c3ccccc3)c(-c3ccccc3)o1)C2

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 5/20 0.50
DRD3 P35462 4/20 0.50
DRD4 P21917 1/20 0.50
NR4A2 P43354 8/20 0.45
CA1 P00915 2/20 0.42
CA2 P00918 2/20 0.42
ACHE P22303 2/20 0.42
NR4A1 P22736 2/20 0.41
NR4A3 Q92570 2/20 0.41
TRPA1 O75762 1/20 0.40
TRPV1 Q8NER1 1/20 0.40
RXRA P19793 2/20 0.40
RXRB P28702 2/20 0.40
RXRG P48443 2/20 0.40
KDM4E B2RXH2 1/20 0.40
ABCC4 O15439 1/20 0.40
C5 P01031 1/20 0.40
LMNA P02545 1/20 0.40
CHRM2 P08172 1/20 0.40
CYP3A4 P08684 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7499160 0.83 PTGIR (0.49) DRD2NR4A2
SCHEMBL7494308 0.81 DRD2 (0.48) DRD2DRD3DRD4NR4A2CA1
SCHEMBL7492298 0.79 DRD2 (0.46) DRD2DRD3DRD4NR4A2CA1
SCHEMBL10043005 0.76 DRD2 (0.71) DRD2DRD3DRD4CA1CA2
SCHEMBL11960199 0.76 DRD2 (0.71) DRD2DRD3DRD4CA1CA2
SCHEMBL10043007 0.76 DRD2 (0.71) DRD2DRD3DRD4CA1CA2
Hydrochloric Acid SCHEMBL11721888 0.75 NR4A2 (0.53) DRD2DRD3NR4A2NR4A1NR4A3
Hydrochloric Acid SCHEMBL11717916 0.74 NR4A2 (0.52) DRD2DRD3NR4A2NR4A1NR4A3
SCHEMBL7485445 0.72 DRD2 (0.47) DRD2DRD3DRD4LMNACYP3A4
SCHEMBL7489309 0.70 TRPA1 (0.43) DRD2DRD3NR4A2NR4A1NR4A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0842161-B1 4,5-DIARYL OXAZOLE DERIVATIVES FUJISAWA PHARMACEUTICAL CO (JP) 2002-09-18 EP disclosed
EP-1213285-A2 4,5-dipheny-oxazole derivatives and their use as platelet aggregation inhibitors FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2002-06-12 EP disclosed
US-6300344-B1 FOR THERAPEUTIC AND/OR PROPHYLACTIC TREATMENT OF ARTERIAL OBSTRUCTION, CEREBROVASCULAR DISEASE, HEPATIC CIRRHOSIS, ARTERIOSCLEROSIS, ISCHEMIC HEART DISEASE, RESTENOSIS AFTER PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY, HYPERTENSION FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-10-09 US disclosed
US-5972965-A USEFUL FOR INHIBITION OF PLATELET AGGREGATION, VASODILATION, ANTIHYPERTENSIVE ACTIVITY AND PROSTAGLANDIN AGONIST FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-10-26 US disclosed
EP-0842161-A1 4,5-DIARYL OXAZOLE DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-05-20 EP disclosed
WO-1997003973-A1 4,5-DIARYL OXAZOLE DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-02-06 WO disclosed